Quercetin (GMP) 

Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a SIRT1 Activator^{[1][2][3][4][5][6]}.

Quercetin GMP (10, 50 and 100 μM) increases osteogenesis of mesenchymal stem cells (mASCs)^[1].
Quercetin GMP (0.1-10 μM) dose-dependently decreases osteoclastogenesis induced by RANKL^[2].
Quercetin GMP (2 μM) dose-dependently enhances the osteogenic differentiation and angiogenic factor secretion of rat bone marrow-derived mesenchymal stem cells (rBMSCs)^[3].
Quercetin GMP (2-5 μM) inhibits bone resorption via inhibiting the differentiation and activation of osteoclasts^[4].
Quercetin (5 μM; 2-4 d) dose-dependently increases osteogenic differentiation^[5].
Quercetin (0-5 μM; 6 d) incresese osteoblastic differentiation and extracellular matrix production and mineralization^[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

302.24

C₁₅H₁₀O₇

117-39-5

OC1=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhou C, Lin Y. Osteogenic differentiation of adipose-derived stem cells promoted by quercetin. Cell Prolif. 2014 Apr;47(2):124-32.  [Content Brief]

  [2]. Wattel A, et al. Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1. J Cell Biochem. 2004 May 15;92(2):285-95.  [Content Brief]

  [3]. Zhou Y, et al. The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells. PLoS One. 2015 Jun 8;10(6):e0129605.  [Content Brief]

  [4]. Woo JT, et al. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9.  [Content Brief]

  [5]. Kim YJ, et al. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78.  [Content Brief]

  [6]. Pang XG, et al. Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. Biomed Res Int. 2018 Mar 15;2018:4178021.  [Content Brief]