Referencia número: HY-18085G

Quercetin (GMP)

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Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a SIRT1 Activator.

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No. CAS: 117-39-5
Fòrmula: C₁₅H₁₀O₇
Peso molecular:302.24

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Quercetin (GMP) Chemical Structure

No. CAS: 117-39-5

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Cellular Effect

Cell Line	Type	Value	Description	References
2008	IC₅₀	21.18 μM Compound: 1, Que	Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A2780	GI₅₀	19.7 μM Compound: Quercetin	Growth inhibition of human A2780 cells incubated for 72 hrs by trypan blue assay Growth inhibition of human A2780 cells incubated for 72 hrs by trypan blue assay	[PMID: 32435372]
A-375	IC₅₀	25.13 μM Compound: 1, Que	Cytotoxicity against human A375 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A375 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A-375	IC₅₀	1.54 ng/mL Compound: 2	Cytotoxicity in human A375 cells Cytotoxicity in human A375 cells	[PMID: 28793973]
A-431	IC₅₀	1.8 μg/mL Compound: quercetin	Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting	[PMID: 1666120]
A-431	IC₅₀	23.04 μM Compound: 1, Que	Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A-431	IC₅₀	34.37 μM Compound: 1, Que	Cytotoxicity against cisplatin-resistant human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against cisplatin-resistant human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
A549	IC₅₀	>20 mg/mL Compound: 18	Cytotoxicity against human A549 cells after 3 days by SRB assay Cytotoxicity against human A549 cells after 3 days by SRB assay	[PMID: 15568778]
A549	IC₅₀	6.2 μM Compound: 1	Anticancer activity against human A549 cells by HTS assay Anticancer activity against human A549 cells by HTS assay	[PMID: 25139569]
A549	IC₅₀	>10 μg/mL Compound: Compound 4	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 25862199]
A549	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 28165740]
A549	IC₅₀	13 μM Compound: Quer	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
ANN-1	IC₅₀	32.5 μM Compound: (2) quercetin	Cytotoxic effect on v-abl transformed murine ANN-1 cells Cytotoxic effect on v-abl transformed murine ANN-1 cells	[PMID: 8201603]
B16-4A5	IC₅₀	15 μM Compound: 17	Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs	[PMID: 20189399]
B16-4A5	IC₅₀	15 μM Compound: 7	Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis	[PMID: 25987378]
BALB/3T3	IC₅₀	217 μM Compound: 5	Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay	[PMID: 10096863]
BT-549	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human BT549 cells after 48 hrs by SRB assay Cytotoxicity against human BT549 cells after 48 hrs by SRB assay	[PMID: 28165740]
BV-2	IC₅₀	29.6 μM Compound: 5, quercetin	Inhibition of LPS-induced NO production in mouse BV2 cells Inhibition of LPS-induced NO production in mouse BV2 cells	[PMID: 18178435]
BV-2	IC₅₀	10 μM Compound: Quercetin	Antiinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production by Griess assay Antiinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production by Griess assay	[PMID: 24707938]
BV-2	IC₅₀	4.3 μM Compound: Quercetin	Inhibition of LPS-stimulated NO production in human BV2 cells after 24 hrs by Griess assay Inhibition of LPS-stimulated NO production in human BV2 cells after 24 hrs by Griess assay	[PMID: 25127164]
BV-2	IC₅₀	17.4 μM Compound: quercetin	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay	[PMID: 26327273]
BV-2	EC₅₀	11 μM Compound: quercetin	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated NO production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated NO production after 24 hrs by Griess assay	[PMID: 26473791]
BV-2	IC₅₀	8.7 μM Compound: Quercetin	Inhibition of LPS-induced nitric oxide production in human BV2 cells after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in human BV2 cells after 24 hrs by Griess assay	[PMID: 26696523]
BV-2	IC₅₀	15.13 μM Compound: Quercetin	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay	[PMID: 27335254]
BV-2	IC₅₀	39.46 μM Compound: 1	Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction	[PMID: 27623545]
BV-2	IC₅₀	19.11 μM Compound: 10	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay	[PMID: 28165740]
BV-2	IC₅₀	16.3 μM Compound: Quercetin	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess reagent based spectrophotometric analysis Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess reagent based spectrophotometric analysis	[PMID: 29122483]
BV-2	IC₅₀	7.2 μM Compound: Quercetin	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay	[PMID: 29303577]
BV-2	IC₅₀	4.3 μM Compound: Quercetin	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 30119995]
BV-2	IC₅₀	2.4 μM Compound: Quercetin	Inhibition of LPS-induced nitric oxide production in mouse BV2 cells after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse BV2 cells after 24 hrs by Griess assay	[PMID: 30132670]
BV-2	IC₅₀	2.4 μM Compound: Quercetin	Antineuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess reagent based assay Antineuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess reagent based assay	[PMID: 31244147]
BV-2	EC₅₀	10.5 μM Compound: Quercetin	Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay	[PMID: 34315042]
BV-2	EC₅₀	9.56 μM Compound: Qc	Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis	[PMID: 34875520]
BV-2	IC₅₀	2.45 μM Compound: Quercetin	Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay	[PMID: 34978437]
BV-2	IC₅₀	6.5 μM Compound: Quercetin	Inhibition of NO production in LPS-induced mouse BV-2 cells incubated for 24 hrs by Griess reagent based microplate reader analysis Inhibition of NO production in LPS-induced mouse BV-2 cells incubated for 24 hrs by Griess reagent based microplate reader analysis	[PMID: 36579935]
BV-2	IC₅₀	7.41 μM Compound: Quercetin	Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay	[PMID: 37530709]
BV-2	IC₅₀	12.58 μM Compound: 96; 99	Anti-inflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay Anti-inflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 37683361]
BV-2	IC₅₀	10 μM Compound: Quercetin	Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 4 hrs followed by LPS addition and measured after 24 hrs by griess reagent based assay Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 4 hrs followed by LPS addition and measured after 24 hrs by griess reagent based assay	[PMID: 38095929]
BV-2	IC₅₀	9.8 μM Compound: Quercetin	Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 3 hrs followed by LPS addition and measured after 21 hrs by griess reagent based assay Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 3 hrs followed by LPS addition and measured after 21 hrs by griess reagent based assay	[PMID: 39140432]
BXPC-3	IC₅₀	24.12 μM Compound: 1, Que	Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
BXPC-3	IC₅₀	16 μM Compound: Quer	Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
C13	IC₅₀	37.62 μM Compound: 1, Que	Cytotoxicity against human C13 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human C13 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
C2C12	IC₅₀	30.79 μg/mL Compound: 3	Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay	[PMID: 33412152]
C6	IC₅₀	18.38 μM Compound: 51	Inhibition of cell proliferation of rat C6 cells assessed as cell viability after 72 hrs by sulforhodamine B assay Inhibition of cell proliferation of rat C6 cells assessed as cell viability after 72 hrs by sulforhodamine B assay	[PMID: 25442304]
C8166	CC₅₀	104.9 μg/mL Compound: 1	Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 24794743]
C8166	EC₅₀	2.05 μg/mL Compound: 1	Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis	[PMID: 24794743]
Calu-1	IC₅₀	23.58 μM Compound: 1	Anticancer activity against human Calu1 cells by HTS assay Anticancer activity against human Calu1 cells by HTS assay	[PMID: 25139569]
CCRF-CEM	IC₅₀	>10 μg/mL Compound: 8	Cytotoxicity against human CEM cells after 3 days by MTT assay Cytotoxicity against human CEM cells after 3 days by MTT assay	[PMID: 11421746]
CHO	EC₅₀	>100 μM Compound: quercetin	Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells	[PMID: 16562853]
COLO 201	IC₅₀	19 μM Compound: Quer	Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
CT26	IC₅₀	14.4 μM Compound: 1	Antiproliferative activity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Antiproliferative activity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 36599228]
CT26	IC₅₀	14.4 μM Compound: 1	Antiproliferative activity against mouse CT26 cells harboring active Wnt/beta-catenin signal assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against mouse CT26 cells harboring active Wnt/beta-catenin signal assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 38097141]
CWR22R	IC₅₀	15.5 μM Compound: 16	Antiproliferative activity against human 22Rv1 cells incubated up to 144 hrs by Coulter particle count and size analyzer Antiproliferative activity against human 22Rv1 cells incubated up to 144 hrs by Coulter particle count and size analyzer	[PMID: 22789812]
DU-145	EC₅₀	>100 μM Compound: Quercetin	Antiproliferative activity against human DU145 cells after 24 hrs by MTT assay Antiproliferative activity against human DU145 cells after 24 hrs by MTT assay	[PMID: 21090565]
DU-145	IC₅₀	>100 μM Compound: Quercetin	Cytotoxicity against human androgen-independent DU145 cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay Cytotoxicity against human androgen-independent DU145 cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay	[PMID: 26341135]
DU-145	IC₅₀	>100 μM Compound: 1	Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay	[PMID: 28760528]
DU-145	IC₅₀	>100 μM Compound: Quercetin	Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay	[PMID: 30165345]
EA.hy 926	EC₅₀	2669.3 nM Compound: Quercetin	Cytoprotective activity against H2O2-induced toxicity in human EA.hy 926 cells assessed as protective rate pretreated with compound for 4 hrs followed by incubation with H2O2 for 2 hrs by absorbance based analysis Cytoprotective activity against H2O2-induced toxicity in human EA.hy 926 cells assessed as protective rate pretreated with compound for 4 hrs followed by incubation with H2O2 for 2 hrs by absorbance based analysis	[PMID: 37625288]
H9	EC₅₀	132 μM Compound: 4	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
H9	IC₅₀	132 μM Compound: 4	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
H9	EC₅₀	1.6 μg/mL Compound: 2	Inhibitory activity against HIV-1 IIIB replication in H9 cell line Inhibitory activity against HIV-1 IIIB replication in H9 cell line	10.1016/0960-894X(94)80015-4
H9	IC₅₀	<4 μg/mL Compound: 2	Inhibitory activity against H9 cells uninfected with HIV-1 Inhibitory activity against H9 cells uninfected with HIV-1	10.1016/0960-894X(94)80015-4
HCT-116	EC₅₀	>100 μM Compound: Quercetin	Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay	[PMID: 21090565]
HCT-116	IC₅₀	23 μM Compound: 2	Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	5.7 μM Compound: 2	Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	6.7 μM Compound: 2	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	43.87 μM Compound: Quercetin	Cytotoxicity against human HCT-116 cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33221062]
HCT-116	IC₅₀	10.44 μM Compound: 1	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 36599228]
HCT-116	IC₅₀	11.41 μM Compound: 1	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 38097141]
HCT-15	IC₅₀	16.35 μM Compound: 1, Que	Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
HEK293	IC₅₀	1.54 μM Compound: 20	Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol	[PMID: 18533708]
HEK293	IC₅₀	0.68 μM Compound: 7a	Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay	[PMID: 20731357]
HEK293	IC₅₀	54.65 μM Compound: 1, Que	Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
HEK293	IC₅₀	6.5 μM Compound: 22	Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fluo-4 dye based fluorescence assay Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fluo-4 dye based fluorescence assay	[PMID: 30943030]
HeLa	IC₅₀	>=10 μM Compound: quercetin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19278239]
HeLa	IC₅₀	3.56 μM Compound: 1	Anticancer activity against human HeLa cells by HTS assay Anticancer activity against human HeLa cells by HTS assay	[PMID: 25139569]
HeLa	IC₅₀	8.26 μg/mL Compound: Compound 4	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 25862199]
HeLa	GI₅₀	17.7 μM Compound: Quercetin	Growth inhibition of human HeLa cells incubated for 72 hrs by trypan blue assay Growth inhibition of human HeLa cells incubated for 72 hrs by trypan blue assay	[PMID: 32435372]
HeLa	IC₅₀	22.5 μM Compound: Quercetin	Cytotoxicity against human HeLa cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HeLa cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 33221062]
HeLa	IC₅₀	4 μM Compound: 30	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 33355454]
HepG2	IC₅₀	>10 μM Compound: quercetin	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 19583252]
HepG2	IC₅₀	30.9 μM Compound: 32	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 21726077]
HepG2	IC₅₀	11 μM Compound: Quercetin	Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced intracellular peroxyl radical scavenging activity by measuring ROS production measured every 5 mins for 1 hr by absorbance assay Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced intracellular peroxyl radical scavenging activity by measuring ROS production measured every 5 mins for 1 hr by absorbance assay	[PMID: 24471493]
HepG2	EC₅₀	4.63 μM Compound: QE	Antioxidant activity in human HepG2 cells assessed as decrease in fluorescence level after 2.5 hrs measured every 5 mins for 1 hr by DCFH-DA staining based fluorescence assay Antioxidant activity in human HepG2 cells assessed as decrease in fluorescence level after 2.5 hrs measured every 5 mins for 1 hr by DCFH-DA staining based fluorescence assay	[PMID: 26974372]
HepG2	EC₅₀	4.63 μmol Compound: QE	Antioxidant activity in human HepG2 cells assessed as decrease in fluorescence level after 2.5 hrs measured every 5 mins for 1 hr by DCFH-DA staining based fluorescence assay Antioxidant activity in human HepG2 cells assessed as decrease in fluorescence level after 2.5 hrs measured every 5 mins for 1 hr by DCFH-DA staining based fluorescence assay	[PMID: 26974372]
HepG2	IC₅₀	12 μM Compound: Quercetin	Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced peroxyl radical generation incubated for 60 mins measured for 60 mins by DCFH-DA probe based fluorescence assay Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced peroxyl radical generation incubated for 60 mins measured for 60 mins by DCFH-DA probe based fluorescence assay	[PMID: 29553260]
HepG2	IC₅₀	65 μM Compound: Quercetin	Antioxidant activity in human HepG2 cells assessed as inhibition of cumene hydroperoxide-mediated lipid peroxidation incubated for 60 mins followed by cumOOH addition for 60 mins measured for 60 mins by C11-BODIPY probe based fluorescence assay Antioxidant activity in human HepG2 cells assessed as inhibition of cumene hydroperoxide-mediated lipid peroxidation incubated for 60 mins followed by cumOOH addition for 60 mins measured for 60 mins by C11-BODIPY probe based fluorescence assay	[PMID: 29553260]
HepG2	IC₅₀	12.5 μM Compound: Quercetin	Neuroprotective activity against H202 induced oxidative stress in human HepG2 cells measured after 1 hr by DCFH-DA staining based analysis Neuroprotective activity against H202 induced oxidative stress in human HepG2 cells measured after 1 hr by DCFH-DA staining based analysis	[PMID: 37567058]
HepG2	IC₅₀	15.1 μM Compound: 96; 99	Anti-inflammatory activity against TNFalpha-induced human HepG2 cells assessed as inhibition of NF-kappaB activity pre-indubated for 1 hr followed by TNFalpha treatment measured for 5 hrs by luciferase based assay Anti-inflammatory activity against TNFalpha-induced human HepG2 cells assessed as inhibition of NF-kappaB activity pre-indubated for 1 hr followed by TNFalpha treatment measured for 5 hrs by luciferase based assay	[PMID: 37683361]
HepG2	IC₅₀	12.5 μM Compound: Quercetin	Antioxidant activity in human HepG2 cells assessed as reduction in H2O2-induced oxidation measured after 60 mins by DCFH-DA staining method Antioxidant activity in human HepG2 cells assessed as reduction in H2O2-induced oxidation measured after 60 mins by DCFH-DA staining method	[PMID: 39002183]
HepG2 2.2.15	CC₅₀	38.1 μM Compound: quercetin	Cytotoxicity against human HepG2(2.2.15) cells after 8 days by MTT assay Cytotoxicity against human HepG2(2.2.15) cells after 8 days by MTT assay	[PMID: 21401115]
HFF	IC₅₀	100 μM Compound: (2) quercetin	Inhibition of PDGF-induced mitogenesis in human foreskin fibroblasts Inhibition of PDGF-induced mitogenesis in human foreskin fibroblasts	[PMID: 8201603]
HL-60	IC₅₀	>10 μg/mL Compound: 8	Cytotoxicity against human HL60 cells after 3 days by MTT assay Cytotoxicity against human HL60 cells after 3 days by MTT assay	[PMID: 11421746]
HL-60	IC₅₀	58 μM Compound: Quercetin	Cytotoxicity against human HL60 cells after 46 hrs by MTT assay Cytotoxicity against human HL60 cells after 46 hrs by MTT assay	[PMID: 23756061]
HL-60	IC₅₀	47 μM Compound: Quercetin	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 25014747]
HL-60	IC₅₀	10 ng/mL Compound: Quercetin	Growth inhibition of human HL60 cells after 72 hrs by MTT assay Growth inhibition of human HL60 cells after 72 hrs by MTT assay	[PMID: 31398616]
HN5	IC₅₀	190 μM Compound: (2) quercetin	Cytotoxic effect on EGF-receptor overexpressing HN5 squamous carcinoma cells Cytotoxic effect on EGF-receptor overexpressing HN5 squamous carcinoma cells	[PMID: 8201603]
HOP-62	IC₅₀	7.52 μM Compound: 1	Anticancer activity against human HOP62 cells by HTS assay Anticancer activity against human HOP62 cells by HTS assay	[PMID: 25139569]
HS27	EC₅₀	>100 μM Compound: Quercetin	Antiproliferative activity against human HS27 cells after 24 hrs by MTT assay Antiproliferative activity against human HS27 cells after 24 hrs by MTT assay	[PMID: 21090565]
Hs-578T	IC₅₀	50.54 μM Compound: Quercetin	Cytotoxicity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Cytotoxicity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 38665823]
HT-22	EC₅₀	2.98 μM Compound: Quercetin	Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells	[PMID: 16392814]
HT-22	EC₅₀	11.52 μM Compound: Quercetin	Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay	[PMID: 24602904]
HT-22	EC₅₀	3.13 μM Compound: Quercetin	Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay	[PMID: 24602904]
HT-29	EC₅₀	8.02 μM Compound: Quercetin	Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay	[PMID: 24900447]
HT-29	IC₅₀	15.4 μM Compound: Quercetin	Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins	[PMID: 24900447]
HT-29	IC₅₀	18 μM Compound: Quer	Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
Huh-7	CC₅₀	>50 μM Compound: 35	Cytotoxicity against human Huh7.5.1 cells by MTT assay Cytotoxicity against human Huh7.5.1 cells by MTT assay	[PMID: 22445328]
Huh-7	EC₅₀	19.8 μM Compound: 35	Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay	[PMID: 22445328]
Huh-7	IC₅₀	99.97 μM Compound: 12a	Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 36692498]
HUVEC	EC₅₀	18 μM Compound: Quercetin	Cytoprotective activity against H2O2-induced cell injury in HUVEC cells Cytoprotective activity against H2O2-induced cell injury in HUVEC cells	[PMID: 20621727]
HUVEC	IC₅₀	>100 μM Compound: 7	Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells	10.1007/s00044-012-0353-y
J774.2	IC₅₀	125.44 μM Compound: 2	Cytotoxicity against BALB/c mouse J774.2 cells after 72 hrs by trypan blue assay Cytotoxicity against BALB/c mouse J774.2 cells after 72 hrs by trypan blue assay	[PMID: 19489596]
J774.A1	IC₅₀	49.1 μM Compound: 1	Inhibition of LPS-induced NO production in mouse J774.A1 cells pre-incubated with compound for 1 hr followed by LPS stimulation for 24 hrs by ELISA assay Inhibition of LPS-induced NO production in mouse J774.A1 cells pre-incubated with compound for 1 hr followed by LPS stimulation for 24 hrs by ELISA assay	[PMID: 34971873]
Jurkat	IC₅₀	5 μM Compound: Quercetin	Activity against hydrogen peroxide induced DNA damage in Jurkat T cells Activity against hydrogen peroxide induced DNA damage in Jurkat T cells	[PMID: 16392814]
Jurkat	IC₅₀	2 μM Compound: Quercetin	Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method	[PMID: 30776692]
Jurkat	IC₅₀	3.5 μM Compound: Quercetin	Inhibition of chymotrypsin-like activity of purified human 20S proteasome expressed in human Jurkat cells assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 2 hrs by fluorescence based method Inhibition of chymotrypsin-like activity of purified human 20S proteasome expressed in human Jurkat cells assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 2 hrs by fluorescence based method	[PMID: 30776692]
K562	IC₅₀	2.5 μM Compound: Quercetin	Cytotoxicity against human K562 cells assessed as inhibition of cell growth after 5 days by MTT assay Cytotoxicity against human K562 cells assessed as inhibition of cell growth after 5 days by MTT assay	[PMID: 29553260]
KB	IC₅₀	136 μg/mL Compound: quercetin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 12398543]
KB	ED₅₀	25 μg/mL Compound: NSC-9219	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 469554]
L6	IC₅₀	>30 μg/mL Compound: 17	Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells after 96 hrs by photometric method Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells after 96 hrs by photometric method	10.1039/C5MD00481K
L929	IC₅₀	>100 μM Compound: Quercetin	Cytotoxicity against mouse L929 cells after 5 days by MTS assay Cytotoxicity against mouse L929 cells after 5 days by MTS assay	[PMID: 22743241]
L929	EC₅₀	20 μM Compound: quercetin	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining	[PMID: 9287415]
L929	EC₅₀	26 μM Compound: quercetin	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay	[PMID: 9287415]
LN-229	IC₅₀	12 μM Compound: Quer	Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
LNCaP	EC₅₀	25 μM Compound: 2, quercetin	Decrease in androgen receptor protein expression in LNCaP cells by Western blotting Decrease in androgen receptor protein expression in LNCaP cells by Western blotting	[PMID: 17383188]
LNCaP	IC₅₀	45.5 μM Compound: Quercetin	Cytotoxicity against human androgen-dependent LNCAP cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay Cytotoxicity against human androgen-dependent LNCAP cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay	[PMID: 26341135]
LNCaP	IC₅₀	45.5 μM Compound: 1	Antiproliferative activity against human LNCAP cells after 3 days by WST1 assay Antiproliferative activity against human LNCAP cells after 3 days by WST1 assay	[PMID: 27476422]
LNCaP	IC₅₀	45.46 μM Compound: 1	Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay	[PMID: 28760528]
LNCaP	IC₅₀	45.5 μM Compound: Quercetin	Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay	[PMID: 30165345]
LOX IMVI	IC₅₀	4.65 μM Compound: 1	Anticancer activity against human LOXIMVI cells by HTS assay Anticancer activity against human LOXIMVI cells by HTS assay	[PMID: 25139569]
M14	IC₅₀	12.77 μM Compound: 1	Anticancer activity against human M14 cells by HTS assay Anticancer activity against human M14 cells by HTS assay	[PMID: 25139569]
MCF-10A	IC₅₀	11.97 μM Compound: Quercetin	Cytotoxicity against human MCF10A cells assessed as decrease in cell viability after 3 days by WST-1 assay Cytotoxicity against human MCF10A cells assessed as decrease in cell viability after 3 days by WST-1 assay	[PMID: 30165345]
MCF-10A	IC₅₀	9.32 μM Compound: Quercetin	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 38665823]
MCF7	IC₅₀	19.5 mg/mL Compound: 18	Cytotoxicity against human MCF7 cells after 3 days by SRB assay Cytotoxicity against human MCF7 cells after 3 days by SRB assay	[PMID: 15568778]
MCF7	IC₅₀	>10 μM Compound: quercetin	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 19583252]
MCF7	EC₅₀	>100 μM Compound: Quercetin	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 21090565]
MCF7	IC₅₀	7.6 μM Compound: 13	Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining	[PMID: 21354800]
MCF7	IC₅₀	20.9 μM Compound: 1, Que	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
MCF7	IC₅₀	5 μM Compound: Quercetin	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay	[PMID: 33257172]
MCF7	IC₅₀	24 μM Compound: (2) quercetin	Cytotoxic effect on MCF-7 human breast carcinoma cells Cytotoxic effect on MCF-7 human breast carcinoma cells	[PMID: 8201603]
MDA-MB-231	IC₅₀	20 μM Compound: Quer	Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
MDCK	CC₅₀	253.8 μM Compound: 4	Cytotoxicity against MDCK cells after 48 hrs by MTT assay Cytotoxicity against MDCK cells after 48 hrs by MTT assay	[PMID: 19729316]
MDCK	EC₅₀	133.6 μM Compound: 4	Antiviral activity against influenza A virus H9N2 A/Chicken/Korea/MS96/96 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect Antiviral activity against influenza A virus H9N2 A/Chicken/Korea/MS96/96 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect	[PMID: 19729316]
MDCK	EC₅₀	43.1 μM Compound: 4	Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect	[PMID: 19729316]
MDCK	IC₅₀	6.9 μM Compound: 13	Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining	[PMID: 21354800]
MDCK	ED₅₀	48.2 μM Compound: 1	Antiviral activity against influenza A virus (A/swine/OH/511445/2007(H1N1)) Oh7 infected in MDCK cells assessed as inhibition of viral replication after 4 days by quantitative RT-PCR Antiviral activity against influenza A virus (A/swine/OH/511445/2007(H1N1)) Oh7 infected in MDCK cells assessed as inhibition of viral replication after 4 days by quantitative RT-PCR	[PMID: 22115591]
MDCK	CC₅₀	253.8 μM Compound: QR	Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay	[PMID: 31744778]
MDCK	EC₅₀	84.46 nM Compound: QR	Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay	[PMID: 31744778]
MIA PaCa-2	IC₅₀	73.5 μM Compound: 12a	Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 36692498]
Monocyte	IC₅₀	120 μM Compound: quercetin	Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA	[PMID: 10096854]
MSTO-211H	GI₅₀	>20 μM Compound: Quercetin	Growth inhibition of human MSTO-211H cells incubated for 72 hrs by trypan blue assay Growth inhibition of human MSTO-211H cells incubated for 72 hrs by trypan blue assay	[PMID: 32435372]
MV4-11	GI₅₀	13.1 μM Compound: 6	Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay	[PMID: 23411073]
N9	IC₅₀	10.22 μM Compound: 2	Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 28073678]
NALM-6	IC₅₀	77.1 μM Compound: Quercetin	Cytotoxicity against human NALM6 cells after 46 hrs by MTT assay Cytotoxicity against human NALM6 cells after 46 hrs by MTT assay	[PMID: 23756061]
NCI/ADR-RES	IC₅₀	22.15 μM Compound: 1, Que	Cytotoxicity against human MCF7/ADR cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7/ADR cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 25906385]
NCI-H1299	IC₅₀	13.6 μM Compound: 1	Anticancer activity against human H1299 cells by HTS assay Anticancer activity against human H1299 cells by HTS assay	[PMID: 25139569]
NCI-H157	IC₅₀	6 μM Compound: 1	Anticancer activity against human NCI-H157 cells by HTS assay Anticancer activity against human NCI-H157 cells by HTS assay	[PMID: 25139569]
NCI-H1792	IC₅₀	3.85 μM Compound: 1	Anticancer activity against human NCI-H1792 cells by HTS assay Anticancer activity against human NCI-H1792 cells by HTS assay	[PMID: 25139569]
NCI-H1944	IC₅₀	10.18 μM Compound: 1	Anticancer activity against human NCI-H1944 cells by HTS assay Anticancer activity against human NCI-H1944 cells by HTS assay	[PMID: 25139569]
NCI-H460	IC₅₀	9.62 μM Compound: 1	Anticancer activity against human H460 cells by HTS assay Anticancer activity against human H460 cells by HTS assay	[PMID: 25139569]
NCI-H460	IC₅₀	12 μM Compound: Quer	Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
NCI-H522	IC₅₀	5.77 μM Compound: 1	Anticancer activity against human NCI-H522 cells by HTS assay Anticancer activity against human NCI-H522 cells by HTS assay	[PMID: 25139569]
Neutrophil	IC₅₀	2.4 μM Compound: Quercetin	Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by luminol enhanced chemiluminescence assay Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by luminol enhanced chemiluminescence assay	[PMID: 17804122]
Neutrophil	IC₅₀	4.7 μM Compound: Quercetin	Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by lucigenin enhanced chemiluminescence assay Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by lucigenin enhanced chemiluminescence assay	[PMID: 17804122]
Neutrophil	IC₅₀	0.7 μM Compound: 4i	Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of HOCl-induced oxidation of APF after 6 mins by fluorescence assay Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of HOCl-induced oxidation of APF after 6 mins by fluorescence assay	[PMID: 23871908]
Neutrophil	IC₅₀	11.3 μM Compound: 4i	Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay	[PMID: 23871908]
Neutrophil	IC₅₀	26 μM Compound: 4i	Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay	[PMID: 23871908]
Neutrophil	IC₅₀	8 μM Compound: 4i	Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of H2O2-induced oxidation of amplex red incubated for 5 mins prior to PMA challenge by fluorescence assay Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of H2O2-induced oxidation of amplex red incubated for 5 mins prior to PMA challenge by fluorescence assay	[PMID: 23871908]
Neutrophil	IC₅₀	4.86 μM Compound: Quercetin	Antioxidant activity in human neutrophils assessed as inhibition of oxidative burst-induced ROS production by chemiluminescence assay Antioxidant activity in human neutrophils assessed as inhibition of oxidative burst-induced ROS production by chemiluminescence assay	[PMID: 24588269]
Neutrophil	IC₅₀	1.8 μM Compound: 7	Inhibition of PMA-induced oxidative burst in human neutrophils by APF assay Inhibition of PMA-induced oxidative burst in human neutrophils by APF assay	[PMID: 25151578]
Neutrophil	IC₅₀	2.7 μM Compound: 7	Inhibition of PMA-induced oxidative burst in human neutrophils by amplex red assay Inhibition of PMA-induced oxidative burst in human neutrophils by amplex red assay	[PMID: 25151578]
Neutrophil	IC₅₀	2.8 μM Compound: 7	Inhibition of PMA-induced oxidative burst in human neutrophils by chemiluminescence assay Inhibition of PMA-induced oxidative burst in human neutrophils by chemiluminescence assay	[PMID: 25151578]
Neutrophil	IC₅₀	20.4 μM Compound: Quercetin	Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in TNFalpha production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in TNFalpha production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA	[PMID: 30109803]
Neutrophil	IC₅₀	33 μM Compound: Quercetin	Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in IL-8 production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in IL-8 production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA	[PMID: 30109803]
Neutrophil	IC₅₀	4.4 μM Compound: Quercetin	Antiinflammatory activity against f-MLP-stimulated human neutrophils assessed as reduction in ROS production incubated for 40 mins measured at intervals of 2 mins by luminol-dependent chemiluminescence assay Antiinflammatory activity against f-MLP-stimulated human neutrophils assessed as reduction in ROS production incubated for 40 mins measured at intervals of 2 mins by luminol-dependent chemiluminescence assay	[PMID: 30109803]
NHDF	IC₅₀	>50 μM Compound: 34	Cytotoxicity against NHDF assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against NHDF assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28671460]
NIH3T3	IC₅₀	39.5 μM Compound: (2) quercetin	Cytotoxic effect on 3T3 cells Cytotoxic effect on 3T3 cells	[PMID: 8201603]
Osteoclast	IC₅₀	5.3 μM Compound: quercetin	Induction of mouse osteoclast apoptosis Induction of mouse osteoclast apoptosis	[PMID: 17994703]
P388	ED₅₀	40 μg/mL Compound: Quercetin	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 3404159]
PANC-1	IC₅₀	62 μM Compound: Quer	Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
PC-12	EC₅₀	68.3 μM Compound: Quercetin	Cytoprotective activity against H2O2-induced cell death in rat PC12 cells assessed as increase in cell viability preincubated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay Cytoprotective activity against H2O2-induced cell death in rat PC12 cells assessed as increase in cell viability preincubated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay	[PMID: 19362850]
PC-12	EC₅₀	58.4 μM Compound: Quercetin	Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay	[PMID: 19673490]
PC-3	IC₅₀	>100 μM Compound: Quercetin	Cytotoxicity against human androgen-independent PC3 cells assessed as cell cell viability after 3 days by WST-1 cell proliferation assay Cytotoxicity against human androgen-independent PC3 cells assessed as cell cell viability after 3 days by WST-1 cell proliferation assay	[PMID: 26341135]
PC-3	IC₅₀	>100 μM Compound: 1	Antiproliferative activity against human PC3 cells after 3 days by WST1 assay Antiproliferative activity against human PC3 cells after 3 days by WST1 assay	[PMID: 27476422]
PC-3	IC₅₀	>100 μM Compound: 1	Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay	[PMID: 28760528]
PC-3	IC₅₀	>100 μM Compound: Quercetin	Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay	[PMID: 30165345]
Peritoneal macrophage	IC₅₀	36 μM Compound: kp20	Inhibition of LPS-stimulated nitric oxide production in ddy mouse peritoneal macrophages measured after 20 hrs by Greiss method Inhibition of LPS-stimulated nitric oxide production in ddy mouse peritoneal macrophages measured after 20 hrs by Greiss method	[PMID: 27955927]
Peritoneal macrophage	IC₅₀	>100 μM Compound: quercetin	Cytotoxicity against mouse Peritoneal macrophages cells after 72 hrs by MTS assay Cytotoxicity against mouse Peritoneal macrophages cells after 72 hrs by MTS assay	[PMID: 22989363]
Peritoneal macrophage	IC₅₀	80.2 μM Compound: 1	Cytotoxicity against Swiss mouse peritoneal macrophages after 72 hrs by AlamarBlue assay Cytotoxicity against Swiss mouse peritoneal macrophages after 72 hrs by AlamarBlue assay	[PMID: 23876028]
PWR-1E	IC₅₀	15.08 μM Compound: Quercetin	Cytotoxicity against human PWR-1E cells assessed as decrease in cell viability after 3 days by WST-1 assay Cytotoxicity against human PWR-1E cells assessed as decrease in cell viability after 3 days by WST-1 assay	[PMID: 30165345]
RAW264.7	IC₅₀	26.8 μM Compound: Quercetin	Inhibition of LPS and INF-gamma-induced NO production in mouse RAW264.7 cells Inhibition of LPS and INF-gamma-induced NO production in mouse RAW264.7 cells	[PMID: 15043424]
RAW264.7	IC₅₀	26.8 μM Compound: Quercetin	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells	[PMID: 16378364]
RAW264.7	IC₅₀	25 μM Compound: quercetin	Inhibition of LPS and INF-alpha-induced nitric oxide production in mouse RAW264.7 cells after 16 hrs Inhibition of LPS and INF-alpha-induced nitric oxide production in mouse RAW264.7 cells after 16 hrs	[PMID: 18027905]
RAW264.7	IC₅₀	26.8 μM Compound: quercetin	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells	[PMID: 18027905]
RAW264.7	IC₅₀	9.6 μM Compound: quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent assay	[PMID: 19555124]
RAW264.7	IC₅₀	11.4 μM Compound: 9	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method	[PMID: 19778086]
RAW264.7	IC₅₀	54.3 μM Compound: Quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess reagent method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess reagent method	[PMID: 20056545]
RAW264.7	IC₅₀	32.1 μM Compound: quercetin	Antiinflammatory activity against mouse RAW264.7 cells assessed as Inhibition of LPS-induced nitric oxide production after 24 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as Inhibition of LPS-induced nitric oxide production after 24 hrs by ELISA	[PMID: 20121165]
RAW264.7	IC₅₀	34.5 μM Compound: Quercetin	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs	[PMID: 20825224]
RAW264.7	IC₅₀	63 μM Compound: 8	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method	[PMID: 21353543]
RAW264.7	IC₅₀	66.6 μM Compound: 8	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs	[PMID: 21353543]
RAW264.7	IC₅₀	95.6 μM Compound: quercetin	Cytotoxicity against mouse RAW264.7 cells after 72 hrs by MTS assay Cytotoxicity against mouse RAW264.7 cells after 72 hrs by MTS assay	[PMID: 22989363]
RAW264.7	IC₅₀	16.4 μM Compound: Quercetin	Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reaction analysis Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reaction analysis	[PMID: 23517145]
RAW264.7	IC₅₀	1.3 μM Compound: Quercetin	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs	[PMID: 23540981]
RAW264.7	IC₅₀	>50 μM Compound: 15	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by griess reaction analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by griess reaction analysis	[PMID: 24679441]
RAW264.7	IC₅₀	2.9 μg/mL Compound: Quercetin	Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as reduction in nitric oxide production after 24 hrs by Griess method based ELISA Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as reduction in nitric oxide production after 24 hrs by Griess method based ELISA	[PMID: 25106885]
RAW264.7	IC₅₀	16.6 μM Compound: Quercetin	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay	[PMID: 25245917]
RAW264.7	IC₅₀	1.8 μM Compound: Quercetin	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay	[PMID: 26143931]
RAW264.7	CC₅₀	>50 μM Compound: Quercetin	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26928174]
RAW264.7	IC₅₀	15 μM Compound: Quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess assay	[PMID: 26928174]
RAW264.7	IC₅₀	15.9 μM Compound: Quercetin	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 27177824]
RAW264.7	IC₅₀	4.41 μM Compound: Quercetin	Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess assay	[PMID: 28427811]
RAW264.7	IC₅₀	6.6 μM Compound: Quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide production	[PMID: 29280630]
RAW264.7	IC₅₀	15.1 μM Compound: Quercetin	Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess assay	[PMID: 32003565]
RAW264.7	IC₅₀	22.7 μM Compound: Quercetin	Inhibition of LPS-induced NO production in mouse RAW264.7 cells by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells by Griess reagent based assay	[PMID: 32118424]
RAW264.7	IC₅₀	4.53 μM Compound: Quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay	[PMID: 32299661]
RAW264.7	IC₅₀	4.2 μM Compound: Quercetin	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by alamarBlue assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by alamarBlue assay	[PMID: 32357011]
RAW264.7	IC₅₀	13.6 μM Compound: Quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production	[PMID: 33422907]
RAW264.7	IC₅₀	16.8 μM Compound: Quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production	[PMID: 33422907]
RAW264.7	IC₅₀	16.9 μM Compound: Quercetin	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta production	[PMID: 33422907]
RAW264.7	IC₅₀	13.6 μM Compound: 96; 99	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA	[PMID: 37683361]
RAW264.7	IC₅₀	14.16 μM Compound: 96; 99	Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production	[PMID: 37683361]
RAW264.7	IC₅₀	16.8 μM Compound: 96; 99	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-1beta production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA	[PMID: 37683361]
RAW264.7	IC₅₀	16.9 μM Compound: 96; 99	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA	[PMID: 37683361]
RAW264.7	IC₅₀	22.5 μM Compound: 96; 99	Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-stimulated IL-6 mRNA level incubated for 3 hrs by RT-qPCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-stimulated IL-6 mRNA level incubated for 3 hrs by RT-qPCR analysis	[PMID: 37683361]
RAW264.7	IC₅₀	35.45 μM Compound: 96; 99	Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-induced IL-6 secretion after 24 hrs by ELISA method Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-induced IL-6 secretion after 24 hrs by ELISA method	[PMID: 37683361]
RBL-1	IC₅₀	0.3 μM Compound: Quercetin	In vitro inhibitory activity against RBL-1 5-LO In vitro inhibitory activity against RBL-1 5-LO	[PMID: 3820229]
RBL-1	IC₅₀	2.0 x 10^-7 M Compound: quercetin	In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined	[PMID: 8254620]
RF/6A	IC₅₀	40 μM Compound: Quercetin	Antimigratory activity in rhesus monkey RF/6A cells measured after 24 hrs by wound assay Antimigratory activity in rhesus monkey RF/6A cells measured after 24 hrs by wound assay	[PMID: 27015547]
RF/6A	IC₅₀	70 μM Compound: Quercetin	Antiproliferative activity in rhesus monkey RF/6A cells measured after 24 to 72 hrs by MTT assay Antiproliferative activity in rhesus monkey RF/6A cells measured after 24 to 72 hrs by MTT assay	[PMID: 27015547]
RS4-11	GI₅₀	21.6 μM Compound: 6	Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay	[PMID: 23411073]
Sf21	IC₅₀	28.6 μM Compound: 5	Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assay Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assay	[PMID: 17378609]
SGC-7901	IC₅₀	7.878 μg/mL Compound: Compound 4	Cytotoxicity against human SGC7901 cells by MTT assay Cytotoxicity against human SGC7901 cells by MTT assay	[PMID: 25862199]
SH-SY5Y	IC₅₀	5.6 μM Compound: Quercetin	Neuroprotective activity against H202 induced oxidative stress in human SH-SY5Y cells measured after 1 hr by DCFH-DA staining based analysis Neuroprotective activity against H202 induced oxidative stress in human SH-SY5Y cells measured after 1 hr by DCFH-DA staining based analysis	[PMID: 37567058]
SH-SY5Y	IC₅₀	5.6 μM Compound: Quercetin	Antioxidant activity in human SH-5Y5Y cells assessed as reduction in H2O2-induced oxidation measured after 60 mins by DCFH-DA staining method Antioxidant activity in human SH-5Y5Y cells assessed as reduction in H2O2-induced oxidation measured after 60 mins by DCFH-DA staining method	[PMID: 39002183]
SK-MEL-2	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay	[PMID: 28165740]
SK-MEL-2	IC₅₀	12 μM Compound: Quer	Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
SK-OV-3	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 28165740]
SW1573	IC₅₀	>10 μg/mL Compound: 8	Cytotoxicity against human SW1573 cells after 3 days by MTT assay Cytotoxicity against human SW1573 cells after 3 days by MTT assay	[PMID: 11421746]
T47D	IC₅₀	11 μM Compound: Quer	Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
U-251	IC₅₀	77.8 μM Compound: 51	Inhibition of cell proliferation of human U251 cells assessed as cell viability after 72 hrs by sulforhodamine B assay Inhibition of cell proliferation of human U251 cells assessed as cell viability after 72 hrs by sulforhodamine B assay	[PMID: 25442304]
U2OS	EC₅₀	5.93 μM Compound: Quercetin	Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay	[PMID: 24900447]
U-87MG ATCC	IC₅₀	23 μM Compound: Quer	Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28654265]
Vero	CC₅₀	151 μg/mL Compound: quercetin	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 1338212]
Vero	IC₅₀	110 μg/mL Compound: 5	Cytotoxicity against african green monkey Vero cells by MTT assay Cytotoxicity against african green monkey Vero cells by MTT assay	[PMID: 18855442]
Vero	CC₅₀	3.32 mM Compound: 14	Cytotoxicity against african green monkey Vero cells incubated for 3 days Cytotoxicity against african green monkey Vero cells incubated for 3 days	[PMID: 32539378]
Vero C1008	CC₅₀	3.32 μM Compound: 41	Cytotoxicity against African green monkey Vero E6 cells by MTT assay Cytotoxicity against African green monkey Vero E6 cells by MTT assay	[PMID: 33486200]
Vero C1008	EC₅₀	83.4 μM Compound: 41	Antiviral activity against SARS-CoV pseudotyped virus infected in Vero E6 cells assessed as reduction in viral replication incubated for 2190 mins by ELISA assay Antiviral activity against SARS-CoV pseudotyped virus infected in Vero E6 cells assessed as reduction in viral replication incubated for 2190 mins by ELISA assay	[PMID: 33486200]
WiDr	IC₅₀	40.2 μM Compound: (2) quercetin	Cytotoxic effect on WiDr human colon cells Cytotoxic effect on WiDr human colon cells	[PMID: 8201603]
WM-115	IC₅₀	177.5 μM Compound: Quercetin	Cytotoxicity against human WM115 cells after 46 hrs by MTT assay Cytotoxicity against human WM115 cells after 46 hrs by MTT assay	[PMID: 23756061]

In Vitro

Quercetin GMP (10, 50 and 100 μM) increases osteogenesis of mesenchymal stem cells (mASCs)^[1].
Quercetin GMP (0.1-10 μM) dose-dependently decreases osteoclastogenesis induced by RANKL^[2].
Quercetin GMP (2 μM) dose-dependently enhances the osteogenic differentiation and angiogenic factor secretion of rat bone marrow-derived mesenchymal stem cells (rBMSCs)^[3].
Quercetin GMP (2-5 μM) inhibits bone resorption via inhibiting the differentiation and activation of osteoclasts^[4].
Quercetin (5 μM; 2-4 d) dose-dependently increases osteogenic differentiation^[5].
Quercetin (0-5 μM; 6 d) incresese osteoblastic differentiation and extracellular matrix production and mineralization^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 117-39-5
Appearance Solid
Peso molecular 302.24
Fòrmula C₁₅H₁₀O₇
Color Light yellow to yellow
SMILES

OC1=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1=O
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Room temperature in continental US; may vary elsewhere.
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Mol Carcinog

Quercetin inhibits endothelial & hepatocellular carcinoma cell crosstalk via reducing extracellular vesicle-mediated VEGFR2 mRNA transfer. [Abstract]

2024 Nov;63(11):2254-2268. PMID: 39171838

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Referencias

[1]. Zhou C, Lin Y. Osteogenic differentiation of adipose-derived stem cells promoted by quercetin. Cell Prolif. 2014 Apr;47(2):124-32. [Content Brief]

[2]. Wattel A, et al. Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1. J Cell Biochem. 2004 May 15;92(2):285-95. [Content Brief]

[3]. Zhou Y, et al. The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells. PLoS One. 2015 Jun 8;10(6):e0129605. [Content Brief]

[4]. Woo JT, et al. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9. [Content Brief]

[5]. Kim YJ, et al. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78. [Content Brief]

[6]. Pang XG, et al. Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. Biomed Res Int. 2018 Mar 15;2018:4178021. [Content Brief]

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Quercetin (GMP)

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Quercetin (GMP)

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