Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica

  • J Nat Prod. 2009 Jul;72(7):1273-8. doi: 10.1021/np900148a.
Yaun-Chao Huang  1 ,  Tsong-Long Hwang ,  Chih-Shiang Chang ,  Yu-Liang Yang ,  Chia-Ning Shen ,  Wen-Ying Liao ,  Sheng-Chih Chen ,  Chih-Chuang Liaw
Affiliations
  • 1. Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung 404, Taiwan, Republic of China.
PMID: 19583252 DOI: 10.1021/np900148a
Abstract

Eight new prenylated Flavonoids, ugonins M-T (1-8), together with five known compounds, ugonins J-L (9-11), 5,4'-dihydroxy-4'',4''-dimethyl-5''-methyl-5''H-dihydrofurano[2'',3'':6,7]flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and Elastase release by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (FMLP/CB).