Kadsuralignans H-K from Kadsura coccinea and their nitric oxide production inhibitory effects

  • J Nat Prod. 2007 Dec;70(12):1999-2002. doi: 10.1021/np070269x.
Heran Li  1 ,  Liyan Wang ,  Zhigang Yang ,  Susumu Kitanaka
Affiliations
  • 1. College of Pharmacy, Nihon University, Funabashi, Chiba, Japan.
PMID: 18027905 DOI: 10.1021/np070269x
Abstract

One new arylnaphthalene lignan named kadsuralignan H ( 1) and three new dibenzocyclooctadiene Lignans, named kadsuralignans I ( 2), J ( 3), and K ( 4), respectively, were isolated from an EtOAc fraction of the 80% acetone extract of Kadsura coccinea. The structures were elucidated on the basis of spectroscopic evidence. Compound 1 is the second arylnaphthalene lignan isolated from the Kadsura genus. Compounds 1 and 3 showed inhibitory activity on nitric oxide (NO) production by the murine macrophage-like cell RAW264.7, which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (INF-gamma).