Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

  • J Nat Prod. 2009 Jun;72(6):1097-101. doi: 10.1021/np900019n.
Yu-Jen Kuo  1 ,  Ping-Chun Hsiao ,  Li-Jie Zhang ,  Ming-Der Wu ,  Yu-Han Liang ,  Hsiu-O Ho ,  Yao-Haur Kuo
Affiliations
  • 1. National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
PMID: 19555124 DOI: 10.1021/np900019n
Abstract

Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 microM against several human tumor cell lines.