Anti-inflammatory labdane diterpenoids from Lagopsis supina

  • J Nat Prod. 2014 Apr 25;77(4):1047-53. doi: 10.1021/np5001329.
Hui Li  1 ,  Man-Man Li ,  Xiao-Qin Su ,  Jing Sun ,  Yu-Fan Gu ,  Ke-Wu Zeng ,  Qian Zhang ,  Yun-Fang Zhao ,  Daneel Ferreira ,  Jordan K Zjawiony ,  Jun Li ,  Peng-Fei Tu
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
PMID: 24707938 DOI: 10.1021/np5001329
Abstract

Ten new labdane Diterpenoids, lagopsins A-H (1-3, 5, 7-10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane Diterpenoids (11-15), were isolated from the whole Plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 14.9-34.9 μM.