Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

  • ACS Med Chem Lett. 2012 Jan 17;3(2):165-9. doi: 10.1021/ml2003058.
Huayun Deng  1 ,  Haibei Hu  1 ,  Shizhang Ling  1 ,  Ann M Ferrie  1 ,  Ye Fang  1
Affiliations
  • 1. Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.
PMID: 24900447 DOI: 10.1021/ml2003058
Abstract

We report the discovery and characterization of natural Phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural Phenols are divergent in their biased agonism.

Keywords
GPR35; biased agonism; ellagic acid; natural phenols.