2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PI3K
  5. PI3KC3 Isoform

PI3KC3

PI3KC3 / VPS34 is the single Class III PI3K that produces PI3P, supporting endosome-lysosome trafficking and autophagy induction[1]. Mechanistically, PI3KC3 complex I contains VPS34, VPS15, BECN1, and ATG14, and initiates macroautophagy through PI3P synthesis at autophagosome formation sites[2]. In autophagy models, VPS34 kinase-domain dynamics regulate PI3KC3-C1 activity and autophagy induction[3]. In disease-relevant systems, PI3KC3 supports vesicular trafficking, endocytosis, and autophagosome-autolysosome formation in podocytes, while endosomal-autophagic-lysosomal dysregulation appears in Alzheimer’s disease mouse brain regions[4][5]. Compared with Class I PI3K isoforms that synthesize PIP3, Class III PI3K synthesizes PI3P and regulates endosome-lysosome trafficking and autophagy[1]. For experimental applications, SAR405 selectively inhibits PIK3C3/VPS34, disrupts late endosome-to-lysosome trafficking, blocks starvation- or MTOR-inhibition-induced autophagy, and synergizes with everolimus in renal tumor cells[6].

PI3KC3 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-112443
    AZD3458
    		Inhibitor 99.71%
    AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively.