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  3. AZD3458

AZD3458 

Cat. No.: HY-112443 Purity: 99.82%
Handling Instructions

AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively.

For research use only. We do not sell to patients.

AZD3458 Chemical Structure

AZD3458 Chemical Structure

CAS No. : 2132961-46-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 270 In-stock
Estimated Time of Arrival: December 31
50 mg USD 680 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].

IC50 & Target[1]

PI3Kγ

9.1 (pIC50)

PI3Kα

5.1 (pIC50)

PI3Kβ

4.5 (pIC50)

PI3Kδ

6.5 (pIC50)

PI3KC2α

5 (pIC50)

PI3KC2β

7.5 (pIC50)

PI3KC2γ

5.5 (pIC50)

PI3KC3

5.1 (pIC50)

In Vitro

AZD3458 (Compound 15) also inhibits PI3KC2α, PI3KC2β, PI3KC2γ, and PI3KC3 with pIC50s of <5, 7.5, 5.5, and 5.1, respectively[1].

Molecular Weight

433.54

Formula

C₂₀H₂₃N₃O₄S₂

CAS No.

2132961-46-5

SMILES

O=C1N([[email protected]@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (576.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3066 mL 11.5330 mL 23.0659 mL
5 mM 0.4613 mL 2.3066 mL 4.6132 mL
10 mM 0.2307 mL 1.1533 mL 2.3066 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AZD3458AZD 3458AZD-3458PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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Product Name:
AZD3458
Cat. No.:
HY-112443
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