1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
    TRP Channel
  3. 2-Aminoethyl diphenylborinate

2-Aminoethyl diphenylborinate (Synonyms: 2-APB)

Cat. No.: HY-W009724 Purity: 98.03%
Handling Instructions

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3).

For research use only. We do not sell to patients.

2-Aminoethyl diphenylborinate Chemical Structure

2-Aminoethyl diphenylborinate Chemical Structure

CAS No. : 524-95-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[1][2][3].

Molecular Weight

225.09

Formula

C₁₄H₁₆BNO

CAS No.

524-95-8

SMILES

NCCOB(C1=CC=CC=C1)C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1110.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4427 mL 22.2133 mL 44.4267 mL
5 mM 0.8885 mL 4.4427 mL 8.8853 mL
10 mM 0.4443 mL 2.2213 mL 4.4427 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2-Aminoethyl diphenylborinate2-APBCalcium ChannelTRP ChannelCa2+ channelsCa channelsTransient receptor potential channelsInhibitorinhibitorinhibit

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Product name:
2-Aminoethyl diphenylborinate
Cat. No.:
HY-W009724
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