2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. Calcium Channel
    TRP Channel
  4. 2-Aminoethyl diphenylborinate

2-Aminoethyl diphenylborinate  (Synonyms: 2-APB)

Cat. No.: HY-W009724 Purity: 98.36%
COA Handling Instructions

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3).

For research use only. We do not sell to patients.

2-Aminoethyl diphenylborinate Chemical Structure

2-Aminoethyl diphenylborinate Chemical Structure

CAS No. : 524-95-8

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
5 mg USD 50 In-stock
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Based on 19 publication(s) in Google Scholar

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Description

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca2+ (SOC) channel and activates some TRP channels (V1, V2 and V3)[1][2][3].

Molecular Weight

225.09

Appearance

Solid

Formula

C14H16BNO
CAS No.
SMILES

NCCOB(C1=CC=CC=C1)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1110.67 mM; Need ultrasonic)

H2O : 1.61 mg/mL (7.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4427 mL 22.2133 mL 44.4267 mL
5 mM 0.8885 mL 4.4427 mL 8.8853 mL
10 mM 0.4443 mL 2.2213 mL 4.4427 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.24 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.36%

COA (248 KB) HNMR (242 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2-Aminoethyl diphenylborinate524-95-82-APBCalcium ChannelTRP ChannelCa2+ channelsCa channelsTransient receptor potential channelsInhibitorinhibitorinhibit

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