1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Apoptosis
  2. Calcium Channel
    Apoptosis
  3. Xestospongin C

Xestospongin C (Synonyms: (-)-Xestospongin C)

Cat. No.: HY-103312
Handling Instructions

Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells.

For research use only. We do not sell to patients.

Xestospongin C Chemical Structure

Xestospongin C Chemical Structure

CAS No. : 88903-69-9

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Description

Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells[1][2][3].

IC50 & Target[1]

IP3R

 

In Vitro

Xestospongin C (XeC; 10 μM; 1 h before Aβ) pretreatment before Aβ1-42 (20 μM; 24 hours) application displays a significant decrease in the early apoptotic rate (9.87%) compared to the Aβ alone treated group (18.38%)[1].
Xestospongin C (10 μM; 1 h before Aβ) and Aβ1-42 (20 μM; 100 s) has significant main effects on the peak value and average values of Ca2+ changes, as well as a significant interaction in primary cultured hippocampal neurons[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Xestospongin C (3 μM; intracerebroventrical injection by a pump for four weeks) ameliorates the disinhibition-like behavior and long term spatial memory deficits of 8-month-old male APP/PS1 mice of Alzheimer's disease[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.71

Formula

C28H50N2O2

CAS No.
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Xestospongin C
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