2. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis
  3. Calcium Channel Apoptosis
  4. Xestospongin C

Xestospongin C  (Synonyms: (-)-Xestospongin C)

Cat. No.: HY-103312 Purity: 99.9%
COA
SDS
Handling Instructions Technical Support

Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells.

For research use only. We do not sell to patients.

CAS No. : 88903-69-9

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10 μg In-stock

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Based on 9 publication(s) in Google Scholar

Xestospongin C Related Antibodies

Top Publications Citing Use of Products

    Xestospongin C purchased from MedChemExpress. Usage Cited in: Brain. 2024 Nov 4;147(11):3764-3779.  [Abstract]

    The representative immunoblots (top) and bar graph (bottom) showed the association of nNOS and CAPON in hippocampus of ICR mice treated with Xestospongin C (XeC) (5 μM).

    Xestospongin C purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Feb 20;10(1):91.  [Abstract]

    Xestospongin C (XeC) (0.1 μM; 1 h) prevented the increase in mRNA levels of ATF4 and CHOP in LPS-induced NRCMs.

    Xestospongin C purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Feb 20;10(1):91.  [Abstract]

    The IP3R inhibitor Xestospongin C (XeC) (0.1 μM; 15 min) inhibited the ATP-induced Ca2+ increase in NRCMs.

    Xestospongin C purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Feb 20;10(1):91.  [Abstract]

    Xestospongin C (XeC) (0.1 μM; 1 h) significantly attenuated the LPS-induced increase in apoptosis of NRCMs.

    Xestospongin C purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2024 Feb 15:343:123167.  [Abstract]

    Xestospongin C (XeC) (2 μM; 72 h) markedly ameliorated ER expansion and rising caspase 3/9 activities in GC-2spd(ts) cells treated with PFOS.

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    • Purity & Documentation

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    • Customer Review

    Description

    Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells[1][2][3].

    IC50 & Target[1]

    IP3R

     

    In Vitro

    Xestospongin C (XeC; 10 μM; 1 h before Aβ) pretreatment before Aβ1-42 (20 μM; 24 hours) application displays a significant decrease in the early apoptotic rate (9.87%) compared to the Aβ alone treated group (18.38%)[1].
    Xestospongin C (10 μM; 1 h before Aβ) and Aβ1-42 (20 μM; 100 s) has significant main effects on the peak value and average values of Ca2+ changes, as well as a significant interaction in primary cultured hippocampal neurons[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Xestospongin C Related Antibodies
    In Vivo

    Xestospongin C (3 μM; intracerebroventrical injection by a pump for four weeks) ameliorates the disinhibition-like behavior and long term spatial memory deficits of 8-month-old male APP/PS1 mice of Alzheimer's disease[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    446.71

    Formula

    C28H50N2O2
    CAS No.
    Appearance

    Solid

    Color

    Colorless to off-white

    SMILES

    [H][C@]1([C@](CCCCCC[C@@](CCN2CCC3)([H])O[C@@]2([H])[C@]3([H])CCCCCC4)([H])CCC5)N5CC[C@]4([H])O1
    Structure Classification
    Initial Source

    a marine sponge, Xestospongia sp.
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 4.47 mg/mL (10.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2386 mL 11.1929 mL 22.3859 mL
    5 mM 0.4477 mL 2.2386 mL 4.4772 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.9%

    SDS (252 KB)

    COA (252 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2386 mL 11.1929 mL 22.3859 mL 55.9647 mL
    5 mM 0.4477 mL 2.2386 mL 4.4772 mL 11.1929 mL
    10 mM 0.2239 mL 1.1193 mL 2.2386 mL 5.5965 mL
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    Xestospongin C Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Xestospongin C88903-69-9(-)-Xestospongin CCalcium ChannelApoptosisCa2+ channelsCa channelsCa2+ releaseAlzheimer’s diseaseapoptosisAPP/PS1 micebehaviorInhibitorinhibitorinhibit

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