Xestospongin C
Based on 11 publication(s) in Google Scholar
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 88903-69-9
- Formula: C28H50N2O2
- Molecular Weight:446.71
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Xestospongin C
More- Nat Chem Biol. 2025 Aug;21(8):1238-1249. [Abstract]
- Brain. 2024 Nov 4;147(11):3764-3779. [Abstract]
- Environ Pollut. 2024 Feb 15:343:123167. [Abstract]
- Cell Death Discov. 2024 Feb 20;10(1):91. [Abstract]
- Bioeng Transl Med. 2025 Dec 5.
- Thromb Haemost. 2025 Mar 6. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Jul 18;1871(8):167990. [Abstract]
- Cell Calcium. 2026 May 23:136:103155. [Abstract]
- J Neurosci. 2026 Feb 3:e0958252026. [Abstract]
- Physiol Rep. 2026 Jun;14(11):e70975. [Abstract]
- bioRxiv. 2025 April 03.
Customer Validation & Images
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WB
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RT-PCR
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Bio/Physico-chemical Assay
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Flow Cytometry
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Cell Imaging/Staining
All Calcium Channel Isoforms
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Biological Activity
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IP3R |
Xestospongin C (XeC; 10 μM; 1 h before Aβ) pretreatment before Aβ1-42 (20 μM; 24 hours) application displays a significant decrease in the early apoptotic rate (9.87%) compared to the Aβ alone treated group (18.38%)[1].
Xestospongin C (10 μM; 1 h before Aβ) and Aβ1-42 (20 μM; 100 s) has significant main effects on the peak value and average values of Ca2+ changes, as well as a significant interaction in primary cultured hippocampal neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 88903-69-9
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Appearance Solid
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Molecular Weight 446.71
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Formula C28H50N2O2
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Color Colorless to off-white
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SMILES
[H][C@]1([C@](CCCCCC[C@@](CCN2CCC3)([H])O[C@@]2([H])[C@]3([H])CCCCCC4)([H])CCC5)N5CC[C@]4([H])O1
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Synonyms
(-)-Xestospongin C
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Structure Classification
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Initial Source
a marine sponge, Xestospongia sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (11)
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Journal Impact Factor
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Most Recent
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Nat Chem Biol
Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload. [Abstract]2025 Aug;21(8):1238-1249. PMID: 39915626 -
Brain
Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours. [Abstract]2024 Nov 4;147(11):3764-3779. PMID: 38701344
Xestospongin C purchased from MedChemExpress. Usage Cited in: Brain. 2024 Nov 4;147(11):3764-3779. [Abstract]
The representative immunoblots (top) and bar graph (bottom) showed the association of nNOS and CAPON in hippocampus of ICR mice treated with Xestospongin C (XeC) (5 μM).
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Environ Pollut
Perturbation of IP3R-dependent endoplasmic reticulum calcium homeostasis by PPARδ-activated metabolic stress leads to mouse spermatocyte apoptosis: A direct mechanism for perfluorooctane sulfonic acid-induced spermatogenic disorders. [Abstract]2024 Feb 15:343:123167. PMID: 38110051
Xestospongin C purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2024 Feb 15:343:123167. [Abstract]
Xestospongin C (XeC) (2 μM; 72 h) markedly ameliorated ER expansion and rising caspase 3/9 activities in GC-2spd(ts) cells treated with PFOS.
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Cell Death Discov
IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway. [Abstract]2024 Feb 20;10(1):91. PMID: 38378646
Xestospongin C purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Feb 20;10(1):91. [Abstract]
Xestospongin C (XeC) (0.1 μM; 1 h) prevented the increase in mRNA levels of ATF4 and CHOP in LPS-induced NRCMs.
Xestospongin C purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Feb 20;10(1):91. [Abstract]
The IP3R inhibitor Xestospongin C (XeC) (0.1 μM; 15 min) inhibited the ATP-induced Ca2+ increase in NRCMs.
Xestospongin C purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Feb 20;10(1):91. [Abstract]
Xestospongin C (XeC) (0.1 μM; 1 h) significantly attenuated the LPS-induced increase in apoptosis of NRCMs.
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Thromb Haemost
Inhibition of IP3 (Inositol 1,4,5-Trisphosphate) Receptors Retards SARS-CoV-2-Induced Endothelial von Willebrand Factor Secretion and Thrombosis. [Abstract]2025 Mar 6. PMID: 40049586 -
Biochim Biophys Acta Mol Basis Dis
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis. [Abstract]2025 Jul 18;1871(8):167990. PMID: 40684959 -
Cell Calcium
Drug repurposing DMSO from an old solvent to a new candidate for the treatment of colitis and sepsis in male mice. [Abstract]2026 May 23:136:103155. PMID: 42235215 -
J Neurosci
A Time-Sensitive Plasticity Distinguishes the Rapid and Sustained Synaptic Actions of Ketamine from Its (2 R,6 R)-Hydroxynorketamine Metabolite. [Abstract]2026 Feb 3:e0958252026. PMID: 41633835 -
Physiol Rep
Monosodium glutamate-mediated Ca2+-dependent intestinal epithelial ion transports in health and IBS-D in male mice. [Abstract]2026 Jun;14(11):e70975. PMID: 42281391 -
Solvent & Solubility
DMSO : 4.47 mg/mL (10.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang ZJ, et al. Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease. J Alzheimers Dis. 2019;72(4):1217-1231. [Content Brief]
[2]. Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG, Molinski TF, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron. 1997 Sep;19(3):723-33. doi: 10.1016/s0896-6273(00)80384-0. PMID: 9331361. [Content Brief]
[3]. Castonguay A, et al. Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse. Cell Calcium. 2002;32(1):39-47. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.2386 mL | 11.1929 mL | 22.3859 mL | 55.9647 mL |
| 5 mM | 0.4477 mL | 2.2386 mL | 4.4772 mL | 11.1929 mL | |
| 10 mM | 0.2239 mL | 1.1193 mL | 2.2386 mL | 5.5965 mL |
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