TRPM7

TRPM7 is a TRP melastatin channel-kinase that conducts divalent and monovalent cations and combines channel and enzymatic activities^[1]. Mechanistically, vascular TRPM7 supports Mg²⁺ homeostasis and regulates vascular smooth muscle cell growth, apoptosis, adhesion, contraction, cytoskeletal organization, and migration^[2]. In inflammation, TRPM7 channel and kinase activity regulate neutrophil transmigration and reactive oxygen species production through Akt/mTOR signaling^[3]. In intestinal disease models, TRPM7 knockdown reduces LPS-induced apoptosis and inflammatory cytokine expression by modulating TLR4/NF-κB and MEK/ERK pathways^[4]. In kidney fibrosis models, TRPM7 expression increases after unilateral ureteral obstruction, while the inhibitor NS8593 reduces tubular and interstitial cell proliferation and TGF-β1/Smad signaling^[5]. Compared with related TRPM6, which is found primarily in epithelial cells, TRPM7 is ubiquitously expressed, making it a broader experimental target for ion-homeostasis and disease-mechanism studies^[2]. For pharmacological research, carvacrol inhibits TRPM7 current and reduces neonatal hypoxic-ischemic brain injury, whereas CBGA suppresses TRPM7 currents through a kinase-domain-dependent mechanism^[6][7].