1909225-07-5
Chemical Structure
TRPM7-IN-1
- CAS No.: 1909225-07-5
- Formula:C23H25N5O3
- Molecular Weight:419.48
InChIKey: PEHHVFAPCHRFCZ-UHFFFAOYSA-N
SMILES: O=C(NC(C1=CC=CC=C1N(C)C)=O)NC2=CC=C(OC3=NC(C)=CC(C)=N3)C(C)=C2
Biological Activity: TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function[1].
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TRPM7-IN-1 | 98.83% | TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function. | ||||||||||||||||||||
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Keywords
