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Art. -Nr.: HY-117481

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NSC-639829

Name: NSC-639829
Brand: MedChemExpress
SKU: HY-117481
Price: 545.00 USD
Availability: InStock
Rating: 5 (1 reviews)

NSC-639829 is a Benzoylphenylurea (BPU) analogue which has antitumor activity. NSC-639829 is promising for research of refractory metastatic cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 134742-19-1
Formel: C₂₁H₂₀BrN₅O₃
Molecular Weight:470.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC-639829 Chemical Structure

CAS. Nr.: 134742-19-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NSC-639829 is a Benzoylphenylurea (BPU) analogue which has antitumor activity. NSC-639829 is promising for research of refractory metastatic cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	0.85 μM Compound: 1	Cytotoxicity against human ASPC1 cell line by MTT assay Cytotoxicity against human ASPC1 cell line by MTT assay	[PMID: 16570932]
CWR22R	IC₅₀	1 μM Compound: 1	Cytotoxicity against human CWR22R cell line by MTT assay Cytotoxicity against human CWR22R cell line by MTT assay	[PMID: 16570932]
Hs 766	IC₅₀	1 μM Compound: 1	Cytotoxicity against human HS766 cell line by MTT assay Cytotoxicity against human HS766 cell line by MTT assay	[PMID: 16570932]
HuCCT-1	IC₅₀	1 μM Compound: 11	Inhibitory concentration of compound against growth of human HuCCT-1 cell line Inhibitory concentration of compound against growth of human HuCCT-1 cell line	[PMID: 15081011]
LAPC4	IC₅₀	0.25 μM Compound: 1	Cytotoxicity against human LAPC4 cell line by MTT assay Cytotoxicity against human LAPC4 cell line by MTT assay	[PMID: 16570932]
LNCaP	IC₅₀	0.5 μM Compound: 1	Cytotoxicity against human LnCaP cell line by MTT assay Cytotoxicity against human LnCaP cell line by MTT assay	[PMID: 16570932]
MIA PaCa-2	IC₅₀	0.85 μM Compound: 1	Cytotoxicity against human Miapaca2 cell line by MTT assay Cytotoxicity against human Miapaca2 cell line by MTT assay	[PMID: 16570932]
PANC-1	IC₅₀	0.7 μM Compound: 1	Cytotoxicity against human Panc1 cell line by MTT assay Cytotoxicity against human Panc1 cell line by MTT assay	[PMID: 16570932]
Panc1005	IC₅₀	5 μM Compound: 1	Cytotoxicity against human Panc1005 cell line by MTT assay Cytotoxicity against human Panc1005 cell line by MTT assay	[PMID: 16570932]
Panc203	IC₅₀	0.95 μM Compound: 1	Cytotoxicity against human Panc203 cell line by MTT assay Cytotoxicity against human Panc203 cell line by MTT assay	[PMID: 16570932]
Panc430	IC₅₀	0.8 μM Compound: 1	Cytotoxicity against human Panc430 cell line by MTT assay Cytotoxicity against human Panc430 cell line by MTT assay	[PMID: 16570932]

Chemical Information

CAS. Nr. 134742-19-1
Molecular Weight 470.32
Formel C₂₁H₂₀BrN₅O₃
SMILES

O=C(NC1=CC=C(C(C)=C1)OC2=NC=C(C=N2)Br)NC(C3=C(N(C)C)C=CC=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Animals and Diseases

Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hallur G, et al. Benzoylphenylurea sulfur analogues with potent antitumor activity. J Med Chem. 2006 Apr 6;49(7):2357-60. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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