Synthesis and antitumor evaluation of benzoylphenylurea analogs

  • Bioorg Med Chem Lett. 2004 May 3;14(9):2213-6. doi: 10.1016/j.bmcl.2004.02.019.
Hallur Gurulingappa  1 ,  Maria L Amador ,  Ming Zhao ,  Michelle A Rudek ,  Manuel Hidalgo ,  Saeed R Khan
Affiliations
  • 1. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.
PMID: 15081011 DOI: 10.1016/j.bmcl.2004.02.019
Abstract

Novel series of benzoylphenylurea analogs 7-10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human Cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7.