2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. NSC639828

NSC639828 

Cat. No.: HY-145330 Purity: 99.91%
COA Handling Instructions

NSC639828 is a potent inhibitor of DNA polymerase α with an IC50 of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease.

For research use only. We do not sell to patients.

NSC639828 Chemical Structure

NSC639828 Chemical Structure

CAS No. : 134742-26-0

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Based on 1 publication(s) in Google Scholar

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Description

NSC639828 is a potent inhibitor of DNA polymerase α with an IC50 of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease[1].

IC50 & Target

DNA polymerase α[1].
Molecular Weight

462.68

Appearance

Solid

Formula

C18H13BrClN5O3
CAS No.
SMILES

O=C(NC1=CC=C(C(Cl)=C1)OC2=NC=C(C=N2)Br)NC(C3=C(N)C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1613 mL 10.8066 mL 21.6132 mL
5 mM 0.4323 mL 2.1613 mL 4.3226 mL
10 mM 0.2161 mL 1.0807 mL 2.1613 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.40 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.91%

COA (246 KB) HNMR (102 KB) LCMS (240 KB)

Handling Instructions (2659 KB)
References
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NSC639828 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NSC639828134742-26-0NSC 639828NSC-639828DNA/RNA SynthesisDNA polymerase αanticancerInhibitorinhibitorinhibit

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