2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Clanfenur

Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication.

For research use only. We do not sell to patients.

Clanfenur Chemical Structure

Clanfenur Chemical Structure

CAS No. : 51213-99-1

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5 mg USD 150 In-stock
10 mg USD 240 In-stock
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Description

Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication[1].

Molecular Weight

335.76

Formula

C16H15ClFN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C=C1)=CC=C1NC(NC(C2=C(C=CC=C2F)N(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (372.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9783 mL 14.8916 mL 29.7832 mL
5 mM 0.5957 mL 2.9783 mL 5.9566 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9783 mL 14.8916 mL 29.7832 mL 74.4579 mL
5 mM 0.5957 mL 2.9783 mL 5.9566 mL 14.8916 mL
10 mM 0.2978 mL 1.4892 mL 2.9783 mL 7.4458 mL
15 mM 0.1986 mL 0.9928 mL 1.9855 mL 4.9639 mL
20 mM 0.1489 mL 0.7446 mL 1.4892 mL 3.7229 mL
25 mM 0.1191 mL 0.5957 mL 1.1913 mL 2.9783 mL
30 mM 0.0993 mL 0.4964 mL 0.9928 mL 2.4819 mL
40 mM 0.0745 mL 0.3723 mL 0.7446 mL 1.8614 mL
50 mM 0.0596 mL 0.2978 mL 0.5957 mL 1.4892 mL
60 mM 0.0496 mL 0.2482 mL 0.4964 mL 1.2410 mL
80 mM 0.0372 mL 0.1861 mL 0.3723 mL 0.9307 mL
100 mM 0.0298 mL 0.1489 mL 0.2978 mL 0.7446 mL
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Clanfenur Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clanfenur51213-99-1Microtubule/TubulinInhibitorinhibitorinhibit

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