TRPM2

TRPM2 is a Ca²⁺-permeable, non-selective cation channel activated by temperature, oxidative stress, and NAD⁺-related metabolites such as ADP-ribose^[1]. Mechanistically, TRPM2 connects reactive oxygen species to Ca²⁺ influx, immune response, apoptosis, and core body temperature regulation^[1]. In inflammatory models, TRPM2-mediated Ca²⁺ influx drives chemokine production in monocytes and aggravates neutrophil infiltration^[2]. TRPM2 also links oxidative stress to NLRP3 inflammasome activation, and Trpm2−/− mice resist crystal- or liposome-induced IL-1β-mediated peritonitis^[3]. In sensory physiology, TRPM2 is required for non-noxious warmth detection in mice, defining a heat-sensitive role distinct from cold- and menthol-activated TRPM8^[4]. For experimental applications, 2-APB rapidly and reversibly inhibits ADP-ribose-, cADPR-, and heat-activated TRPM2, while ACA inhibits H₂O₂-induced TRPM2-mediated Ca²⁺ entry in β-cells^[5][6].