2765255-93-2
2765255-93-2
Chemical Structure
JNJ-28583113
- CAS No.: 2765255-93-2
- Formula:C19H21F3N2O2
- Molecular Weight:366.38
IUPAC Name: ethyl 2-(3-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4H)-yl)acetate
InChIKey: WOERTJPEDOUEDS-UHFFFAOYSA-N
SMILES: O=C(CN1N=C(C2=C1CCCCC2)C3=CC=C(C(F)(F)F)C=C3)OCC
Biological Activity: JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia[1].
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JNJ-28583113 | 98.82% | JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia. | ||||||||||||||||||||
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