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Cat. No.: HY-123228

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CHF5022

CHF5022 is an inhibitor of Aβ42 secretion (IC₅₀=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (−22.2±4.8% at 100 μM).

For research use only. We do not sell to patients.

CAS No.: 749269-77-0
Formula: C₁₇H₁₂F₄O₂
Molecular Weight:324.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CHF5022 Chemical Structure

CAS No.: 749269-77-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CHF5022 is an inhibitor of Aβ42 secretion (IC₅₀=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (−22.2±4.8% at 100 μM)^[1].

In Vitro

CHF5022 dose not inhibit COX-1 and COX-2 up to a concentration of 300 μM^[1].
CHF5022 (100 μM) significantly downregulated two AICD (APP intracellular domain)-responsive genes, without any effect on the tested NICD (Notch intracellular domain) target genes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

After multiple oral administration, CHF5022 is absorbed dose-dependently, with a fair penetration of the brain (≈10%) of young Tg2575 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 749269-77-0
Molecular Weight 324.27
Formula C₁₇H₁₂F₄O₂
SMILES

O=C(C1(C2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C(F)=C2)CC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55(4):318-28. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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