1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. A-935142

A-935142 

Cat. No.: HY-113673
Handling Instructions

A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization.

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A-935142 Chemical Structure

A-935142 Chemical Structure

CAS No. : 1031335-85-9

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Description

A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization[1][2].

In Vitro

A-935142 shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers[1].
A-935142 shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner. A-935142 (60μM) increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation. A-935142 significantly reduces the time constants (tau) of hERG channel activation at two example voltages (-10 mV: tau=100+/-17 ms vs. 164+/-24 ms, n=6, P<0.01; +30 mV: tau=16.7+/-1.8 ms vs. 18.9+/-1.8 ms, n=5, P<0.05) and shifts the voltage-dependence for hERG activation in the hyperpolarizing direction by 9 mV[2].

Molecular Weight

352.35

Formula

C₁₈H₁₉F₃N₂O₂

CAS No.

1031335-85-9

SMILES

O=C(O)C[[email protected]]1CC[[email protected]](C2=CC=C(C3=NNC(C(F)(F)F)=C3)C=C2)CC1

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Keywords:

A-935142A935142A 935142Potassium ChannelKcsAcurrentamplitudevoltagecomplexInhibitorinhibitorinhibit

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