1031335-85-9
1031335-85-9
Chemical Structure
A-935142
- CAS No.: 1031335-85-9
- Formula:C18H19F3N2O2
- Molecular Weight:352.35
IUPAC Name: 2-((1r,4r)-4-(4-(5-(trifluoromethyl)-1H-pyrazol-3-yl)phenyl)cyclohexyl)acetic acid
InChIKey: YPHFQSYEKIEMNC-HAQNSBGRSA-N
SMILES: O=C(O)C[C@H]1CC[C@H](C2=CC=C(C3=NNC(C(F)(F)F)=C3)C=C2)CC1
Biological Activity: A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization[1][2].
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A-935142 | 98.77% | A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization. | ||||||||||||||||||||
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References
- [1]. Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473. [Content Brief]
- [2]. Liu X, et al.Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers. Life Sci. 2012 Apr 20;90(15-16):607-11. [Content Brief]
Keywords
