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Cat. No.: HY-183531

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p38 MAP Kinase-IN-4

p38 MAP Kinase-IN-4 is a p38α MAPK inhibitor with an IC₅₀ of 40.5 nM. p38 MAP Kinase-IN-4 is applicable to inflammation-related research.

For research use only. We do not sell to patients.

CAS No.: 1228148-61-5
Formula: C₂₁H₂₁F₃N₄
Molecular Weight:386.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

p38 MAP Kinase-IN-4 Chemical Structure

CAS No.: 1228148-61-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

p38 MAP Kinase-IN-4 is a p38α MAPK inhibitor with an IC₅₀ of 40.5 nM. p38 MAP Kinase-IN-4 is applicable to inflammation-related research^[1].

All p38 MAPK Isoforms :

In Vitro

p38 MAP Kinase-IN-4 inhibits p38α kinase with an IC₅₀ of 40.5 nM and shows 93-fold selectivity over p38β kinase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1228148-61-5
Molecular Weight 386.42
Formula C₂₁H₂₁F₃N₄
SMILES

FC(F)(F)C=1C=CC(=CC1)C2=NNC(=C2C=3C=CN=CC3)C4CCN(C)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010;20(8):2634-2638. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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p38 MAP Kinase-IN-4

All p38 MAPK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

p38 MAP Kinase-IN-4 Related Classifications

HY-183531 Related Classifications