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Cat. No.: HY-181481

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2'-Deoxyadenosine-5'-O-diphosphoribose sodium

2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a TRPM2 agonist. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium enhances calcium-induced currents in inside-out patch-clamp experiments using HEK293 cells expressing human TRPM2. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a substrate for Nucleoside Triphosphate Diphosphatase 9 (NUDT9).

For research use only. We do not sell to patients.

Formula: C₁₅H₂₁N₅Na₂O₁₃P₂
Molecular Weight:587.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

2'-Deoxyadenosine-5'-O-diphosphoribose sodium Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target^[1]

TRPM2

All TRP Channel Isoforms :

In Vitro

2'-Deoxyadenosine-5'-O-diphosphoribose sodium (30 µM) enhances calcium-induced currents in inside-out patch-clamp experiments using HEK293 cells expressing human TRPM2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 587.28
Formula C₁₅H₂₁N₅Na₂O₁₃P₂
SMILES

O[C@H]1C[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)(O[Na])=O)(O[Na])=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gattkowski, et al. Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9. FEBS J. 288(23), 6769-6782 (2021). [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

2'-Deoxyadenosine-5'-O-diphosphoribose sodium

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Biological Activity
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- In Vitro
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Purity & Documentation
References

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2'-Deoxyadenosine-5'-O-diphosphoribose sodium

All TRP Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

2'-Deoxyadenosine-5'-O-diphosphoribose sodium Related Classifications

HY-181481 Related Classifications

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