1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. TRP Channel
  4. TRP Channel Inhibitors

TRP Channel Inhibitors

TRPC

TRPM

TRPV

TRPA

TRPML

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TRP Channel Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name TRPC TRPM TRPV TRPA TRPML Purity
Rosiglitazone
TRPC5, EC50: 30 μM
        99.90%
TRPV2-selective blocker 1    
TRPV2, IC50: 6.3 μM
    99.84%
GSK1016790A    
TRPV4
    99.79%
(1R,2R)-ML-SI3        
TRPML1, IC50: 1.6 μM
TRPML2, IC50: 2.3 μM
TRPML3, IC50: 12.5 μM
99.45%
SB-366791    
hTRPV1, IC50: 5.7 nM
    98.72%
ML-SI3        
TRPML1, IC50: 4.7 μM
ML204
TRPC4
TRPC5
        99.08%
Acoltremon  
TRPM8
      99.90%
CIM0216  
TRPM3
      99.77%
Dihydrocapsaicin    
TRPV1
    99.86%
JNJ-28583113  
TRPM2
      98.06%
RQ-00203078  
TRPM8, IC50: 5.3 nM (Rat TRPM8 channels)
TRPM8, IC50: 8.3 nM (Human TRPM8 channels)
TRPV4, IC50: 10 μM
    99.84%
SET2    
TRPV2, IC50: 0.46 μM
    99.72%
AP-18      
TRPA1, IC50: ~3 μM
  99.80%
(rel)-ML-SI3        
TRPML1, IC50: 3.1 μM
TRPML2, EC50: 3.3 μM
TRPML3, IC50: 28.5 μM
99.81%
SOR-C13 TFA    
TRPV6, IC50: 14 nM
    99.18%
LE135    
TRPV1, EC50: 2.5 μM
TRPA1, EC50: 20 μM
  99.03%
Capsiate    
TRPV1
    99.51%
PF-04745637      
TRPA1, IC50: 17 nM
  99.97%
Larixyl acetate
hTRPC6, IC50: 0.58 μM
hTRPC3, IC50: 6.83 μM
        99.46%
JNJ-17203212    
TRPV1
    99.94%
M8-B  
TRPM8
      99.78%
TRPV3 antagonist 74a    
TRPV3
    ≥98.0%
MSP-3    
TRPV1, EC50: 0.87 μM
    98.53%
Chembridge-5861528      
TRPA1, IC50: 14.3 μM (allyl isothiocyanate-evoked TRPA1 response)
TRPA1, IC50: 18.7 μM (4-HNE-evoked TRPA1 response)
  99.76%
TRPV1 antagonist 3  
TRPM8, IC50: 7.45 μM
hTRPV1, IC50: 2.66 nM
    99.30%
Vanilloid receptor antagonist 1    
TRPV1
    98.07%
AS1269574      
TRPA1
  98.76%
ML204 hydrochloride
TRPC4
TRPC5
        99.81%
MDR-652    
hTRPV1, Ki: 11.4 nM
rTRPV1, Ki: 23.8 nM
hTRPV1, EC50: 5.05 nM
rTRPV1, EC50: 93 nM
    99.02%
TRPA1-IN-2      
TRPA1, IC50: 0.04 μM
  99.82%
(1S,2S)-ML-SI3        
TRPML1, IC50: 5.9 μM
TRPML2, EC50: 2.7 μM
TRPML3, EC50: 10.8 μM
99.82%
D-erythro-Sphingosine hydrochloride  
TRPM3
     
Chrysin 6-C-glucoside 8-C-arabinoside    
TRPV1
    99.11%
ABT-102    
TRPV1
   
SOR-C13    
TRPV6, IC50: 14 nM
   
FAAH/TRPV1 blocker-1    
TRPV1, IC50: 94.9 μM
   
Methyl kakuol      
TRPA1
 
TRPV4 antagonist 4    
TRPV4, IC50: 22.65 nM
   
TRPC antagonist 1
TRPC3, IC50: 2.4 μM
TRPC4, IC50: 12.2 μM
TRPC5, IC50: 7.6 μM
TRPC6, IC50: 2.9 μM
TRPC7, IC50: 3.4 μM
       
17(R)-Resolvin D1    
TRPV3, IC50: 398 nM
   
L-R4W2 TFA    
TRPV1, IC50: 0.1 μM
   
5-Iodoresiniferatoxin    
rTRPV1, IC50: 0.7 nM
hTRPV1, IC50: 5.4 nM
   
L-R4W2    
TRPV1, IC50: 0.1 μM
   
MK-2295    
TRPV1
   
GDC-0334      
TRPA1
 
Xeniafaraunol A  
TRPM7
     
Dihydrocapsiate    
TRPV1
    99.18%
TRPV1 antagonist 5    
TRPV1
   
AMG8788      
TRPA1, IC50: 1 μM
 
AMG9678      
TRPA1, IC50: 0.6 μM
 
N-Arachidonyldopamine    
TRPV1, EC50: ~50 nM
   
TRPM8-IN-1  
TRPM8, IC50: <5 μM
     
TRPC5-IN-4
TRPC5, IC50: 14.07 nM
TRPC4, IC50: 65 nM
       
V116517    
TRPV1
   
N-Arachidonoyl Taurine    
TRPV1, EC50: 28 μM
TRPV4, Ki: 21 μM
   
TRPML1 agonist 1        
TRPML1, IC50: 0.27 μM
TRPV6-IN-1    
TRPV6