1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Epigenetics
    TGF-beta/Smad
    Anti-infection
    Apoptosis
  2. Calcium Channel
    PKC
    Bacterial
    Apoptosis
    Antibiotic
  3. Ionomycin

Ionomycin (Synonyms: SQ23377)

Cat. No.: HY-13434 Purity: ≥99.0%
Handling Instructions

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

For research use only. We do not sell to patients.

Ionomycin Chemical Structure

Ionomycin Chemical Structure

CAS No. : 56092-81-0

Size Price Stock Quantity
Solution
1 mg (14.1 mM * 100 μL in Ethanol) USD 110 In-stock
Estimated Time of Arrival: December 31
Solution
5 mg (14.1 mM * 500 μL in Ethanol) USD 390 In-stock
Estimated Time of Arrival: December 31
Solution
10 mg (14.1 mM * 1 mL in Ethanol) USD 630 In-stock
Estimated Time of Arrival: December 31

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Customer Review

Based on 21 publication(s) in Google Scholar

Other Forms of Ionomycin:

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Description

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].

IC50 & Target

Calcium ionophore[1]

In Vitro

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

709.01

Formula

C41H72O9

CAS No.
SMILES
Structure Classification
Source

Streptomyces conglobatus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (141.04 mM; Need ultrasonic)

In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: ≥99.0%

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Ionomycin
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