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Ionomycin

(Synonyms: SQ23377)
132 Cited Publications
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Based on 132 publication(s) in Google Scholar

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

For research use only. We do not sell to patients.

  • Purity: 99.27%
  • CAS No.: 56092-81-0
  • Formula: C41H72O9
  • Molecular Weight:709.01
  • Storage:

    Solution, -20°C, 2 years

  • Ionomycin Chemical Structure
    Ionomycin Chemical Structure
  • Experimental Validation Results for Ionomycin
  • Experimental Validation Results for Ionomycin
  • Experimental Validation Results for Ionomycin
  • Experimental Validation Results for Ionomycin
  • Experimental Validation Results for Ionomycin
  • Experimental Validation Results for Ionomycin
  • Experimental Validation Results for Ionomycin
CAS No.: 56092-81-0
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Cell Imaging/StainingFlow CytometryRT-PCRELISAIF
  • RT-PCR
  • Flow Cytometry
  • Cell Imaging/Staining
  • IF
  • RT-PCR
  • ELISA
  • Cell Imaging/Staining

All Calcium Channel Isoforms

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All PKC Isoforms

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All Antibiotic Isoforms

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  • Ionomycin Chemical Structure
    Ionomycin Chemical Structure
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  • 1/16

    Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102. [Abstract]

    Customer Validation
     CcPKCα modulation by Ionomycin (1 μM in 0.1% DMSO)

  • 1/16

    Ionomycin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Mar 15;83(6):906-921. [Abstract]

    Customer Validation
     The expression of IFNγ or TNFα in CD8+ T cells isolated from B16 tumors was analyzed after re-stimulation by PMA, Ionomycin (500 ng/mL), and BFA for 4 hours in vitro.

  • 1/16

    Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2203869. [Abstract]

    Customer Validation
     Ionomycin (10 μM) served as the positive drug quenching mitochondrial calcein fluorescence.

  • 1/16

    Ionomycin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2023 Mar 1:303:116031. [Abstract]

    Customer Validation
     Calcium imaging in HEK293T cells expressing E649A, E652K, and E652D mutants responds to 10 nM capsaicin, the cocktail of 10 nM capsaicin and 30 μM s-RhTx, 10 μM capsaicin, and 10 μM Ionomycin, respectively.

  • 1/16

    Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301. [Abstract]

    Customer Validation
     Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to RT-qPCR.

  • 1/16

    Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301. [Abstract]

    Customer Validation
     Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to ELISA.

  • 1/16

    Ionomycin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Jul 7;82(13):2401-2414.e9. [Abstract]

    Customer Validation
     Representative images of undivided OT-I CD8+ T cells activated on slides coated with anti-CD3, anti-CD28, and ICAM1 or with PMA plus Ionomycin (1 μM) for 2 h.

  • Ionomycin