1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Epigenetics
    TGF-beta/Smad
    Anti-infection
    Apoptosis
  2. Calcium Channel
    PKC
    Bacterial
    Apoptosis
    Antibiotic
  3. Ionomycin

Ionomycin (Synonyms: SQ23377)

Cat. No.: HY-13434 Purity: >99.0%
Handling Instructions

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

For research use only. We do not sell to patients.

Ionomycin Chemical Structure

Ionomycin Chemical Structure

CAS No. : 56092-81-0

Size Price Stock Quantity
1 mg (14.1 mM * 100 μL in Ethanol) USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg (14.1 mM * 500 μL in Ethanol) USD 390 In-stock
Estimated Time of Arrival: December 31

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Based on 2 publication(s) in Google Scholar

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Description

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].

IC50 & Target

Calcium ionophore[1]

In Vitro

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].

Clinical Trial
Molecular Weight

709.01

Formula

C₄₁H₇₂O₉

CAS No.

56092-81-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Solvent & Solubility
In Vitro: 

Ethanol : ≥ 10 mg/mL (14.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4104 mL 7.0521 mL 14.1042 mL
5 mM 0.2821 mL 1.4104 mL 2.8208 mL
10 mM 0.1410 mL 0.7052 mL 1.4104 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >99.0%

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Keywords:

IonomycinSQ23377SQ 23377SQ-23377Calcium ChannelPKCBacterialApoptosisAntibioticCa2+ channelsCa channelsProtein kinase CcleavageexosomecalciumionophoreantibioticInhibitorinhibitorinhibit

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Ionomycin
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