1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Epigenetics
    TGF-beta/Smad
    Apoptosis
  2. Calcium Channel
    PKC
    Apoptosis
  3. Ionomycin

Ionomycin (Synonyms: SQ23377)

Cat. No.: HY-13434 Purity: >99.0%
Handling Instructions

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

For research use only. We do not sell to patients.

Ionomycin Chemical Structure

Ionomycin Chemical Structure

CAS No. : 56092-81-0

Size Price Stock Quantity
1 mg (14.1 mM * 100  μL in Ethanol) USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg (14.1 mM * 500  μL in Ethanol) USD 390 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].

IC50 & Target

Calcium ionophore[1]

In Vitro

It is observed that LCLC 103H cells overexpressing the catalytic subunit of μ-calpain rapidly underwent cell death after treatment with ionomycin. The first signs of Ionomycin (SQ23377)-induced cell death are detected 3 h after addition of the ionophore. Addition of 2 μM Ionomycin (SQ23377) to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. Remarkably, calcium concentrations are raised transiently to 0.8-1.5 μM. DNA and protein analysis in Ionomycin (SQ23377)-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin (SQ23377) treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin (SQ23377) treatment[3].

Clinical Trial
Molecular Weight

709.01

Formula

C₄₁H₇₂O₉

CAS No.

56092-81-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Solvent & Solubility
In Vitro: 

Ethanol : ≥ 10 mg/mL (14.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4104 mL 7.0521 mL 14.1042 mL
5 mM 0.2821 mL 1.4104 mL 2.8208 mL
10 mM 0.1410 mL 0.7052 mL 1.4104 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >99.0%

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Keywords:

IonomycinSQ23377SQ 23377SQ-23377Calcium ChannelPKCApoptosisCa2+ channelsCa channelsProtein kinase CInhibitorinhibitorinhibit

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Ionomycin
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