1. Membrane Transporter/Ion Channel
  2. Calcium Channel
  3. Ionomycin

Ionomycin (Synonyms: SQ23377)

Cat. No.: HY-13434 Purity: >98.0%
Handling Instructions

Ionomycin (SQ23377) is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005.

For research use only. We do not sell to patients.

Ionomycin Chemical Structure

Ionomycin Chemical Structure

CAS No. : 56092-81-0

Size Price Stock Quantity
14.1 mM*100  μL in Ethanol USD 110 In-stock
Estimated Time of Arrival: December 31
14.1 mM*500  μL in Ethanol USD 390 In-stock
Estimated Time of Arrival: December 31
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5 mg   Get quote  

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Description

Ionomycin (SQ23377) is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005.

IC50 & Target

Calcium channel[1].

In Vitro

Ionomycin (SQ23377) is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus ATCC 31005[1]. It is observed that LCLC 103H cells overexpressing the catalytic subunit of μ-calpain rapidly underwent cell death after treatment with ionomycin. The first signs of Ionomycin (SQ23377)-induced cell death are detected 3 h after addition of the ionophore. Addition of 2 μM Ionomycin (SQ23377) to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. Remarkably, calcium concentrations are raised transiently to 0.8-1.5 μM. DNA and protein analysis in Ionomycin (SQ23377)-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin (SQ23377) treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin (SQ23377) treatment[2].

Clinical Trial
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 10 mg/mL (14.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4104 mL 7.0521 mL 14.1042 mL
5 mM 0.2821 mL 1.4104 mL 2.8208 mL
10 mM 0.1410 mL 0.7052 mL 1.4104 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

709.01

Formula

C₄₁H₇₂O₉

CAS No.

56092-81-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Ionomycin
Cat. No.:
HY-13434
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Ionomycin

Cat. No.: HY-13434