1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKC Isoform

PKC

 

PKC Related Products (125):

Cat. No. Product Name Effect Purity
  • HY-18739
    Phorbol 12-myristate 13-acetate
    Activator 99.66%
    Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator.
  • HY-15141
    Staurosporine
    Inhibitor 99.98%
    Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively.
  • HY-13434
    Ionomycin
    Activator ≥99.0%
    Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus.
  • HY-13502
    Mitoxantrone
    Inhibitor 98.36%
    Mitoxantrone is a potent topoisomerase II inhibitor.
  • HY-13867
    Bisindolylmaleimide I
    Inhibitor 99.03%
    Bisindolylmaleimide I (GF109203X) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor with a Ki of 14 nM.
  • HY-10341
    Fasudil Hydrochloride
    Inhibitor 99.96%
    Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.
  • HY-13434A
    Ionomycin calcium
    Activator ≥98.0%
    Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus.
  • HY-13502A
    Mitoxantrone dihydrochloride
    Inhibitor 99.55%
    Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor.
  • HY-N0021
    Verbascoside
    Inhibitor 99.83%
    Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.
  • HY-13866
    Ro 31-8220 mesylate
    Inhibitor 99.28%
    Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
  • HY-N0453
    Hypericin
    Inhibitor ≥98.0%
    Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L.
  • HY-101047
    D-erythro-Sphingosine
    Inhibitor ≥98.0%
    D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC).
  • HY-18985
    Phorbol 12,13-dibutyrate
    Activator 98.78%
    Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter.
  • HY-11009
    CGP60474
    Inhibitor 98.70%
    CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively).
  • HY-10183
    Go6976
    Inhibitor 99.34%
    Go6976 is a Protein Kinase C (PKC) inhibitor, with an IC50 of 20 nM.
  • HY-12048
    Chelerythrine chloride
    Inhibitor 98.86%
    Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM.
  • HY-12307
    (-)-Indolactam V
    Activator 99.30%
    (-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.
  • HY-18981
    Decursin
    Activator 99.94%
    Decursin ((+)-Decursin) is a potent anti-tumor agent.
  • HY-108355
    R59949
    Activator ≥99.0%
    R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM.
  • HY-12359
    TPPB
    Activator 99.81%
    TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9 nM.