1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKC Inhibitors

PKC Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKCι

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Sorry. There is currently no product that acts on isoform PKC together.

Please try each isoform separately.

PKC Specific Inhibitors, Antagonists & Activators
Product Name PKC PKCα PKCβ PKCγ PKCε PKC Selectivity Purity
Bisindolylmaleimide X hydrochloride
PKC
        Selective Inhibitor 98.53%
KT5823
PKC, Ki: 4 μM
        Selective Inhibitor ≥99.0%
[Ala113]MBP(104-118)
PKC, IC50: 28-62 μM
        Selective Inhibitor
Bisindolylmaleimide IV
PKC, IC50: 0.1-0.55 μM
        Selective Inhibitor
[Ala107]MBP(104-118)
PKC, IC50: 46-145 μM
        Selective Inhibitor
[Ala113]MBP(104-118) TFA
PKC, IC50: 28-62 μM
        Selective Inhibitor
Bisindolylmaleimide VIII acetate
Rat Brain PKC, IC50: 158 nM
PKC-α, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKC-γ, IC50: 213 nM
PKC-ε, IC50: 175 nM
Selective Inhibitor
[Ala107]MBP(104-118) TFA
PKC, IC50: 46-145 μM
        Selective Inhibitor
Phorbol 12-myristate 13-acetate
PKC, EC50: 11.7 nM
        Pan Activator ≥98.0%
Staurosporine
PKC, IC50: 6 nM
        Pan Inhibitor ≥98.0%
Mitoxantrone
PKC, IC50: 8.5 μM
        Pan Inhibitor ≥98.0%
Bisindolylmaleimide I
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
PKCγ, IC50: 20 nM
  Pan Inhibitor 98.14%
Fasudil Hydrochloride
PKC, IC50: 12.30 μM
        Pan Inhibitor ≥95.0%
Chelerythrine chloride
PKC, IC50: 660 nM
        Pan Inhibitor ≥98.0%
Ro 31-8220 mesylate
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
PKC-ε, IC50: 24 nM
Pan Inhibitor ≥98.0%
Mitoxantrone dihydrochloride
PKC, IC50: 8.5 μM
        Pan Inhibitor 98.01%
CGP60474
PKC
        Pan Inhibitor 98.70%
D-erythro-Sphingosine
PKC
        Pan Inhibitor ≥98.0%
Verbascoside
PKC, IC50: 25 μM
        Pan Inhibitor 99.83%
Daphnetin
PKC, IC50: 25.01 μM
        Pan Inhibitor 99.21%
TPPB
PKC, Ki: 11.9 nM
        Pan Activator 99.81%
Ingenol
PKC, Ki: 30 μM
        Pan Activator 98.17%
Valrubicin
TPA-activated PKC, IC50: 0.85 μM
PDBu-activated PKC, IC50: 1.25 μM
        Pan Inhibitor 99.95%
HA-100
PKC, IC50: 12 μM
PKC, Ki: 6.5 μM
        Pan Inhibitor 99.77%
R 59-022
PKC
        Pan Activator ≥99.0%
SB-218078
PKC, IC50: 1000 nM
        Pan Inhibitor ≥98.0%
Chelerythrine
PKC, IC50: 0.7 μM
        Pan Antagonist
A-3 hydrochloride
PKC, Ki: 47 μM
        Pan Inhibitor 99.67%
TAS-301
PKC
        Pan Inhibitor 99.50%
Fasudil
PKC, IC50: 12.3 μM
        Pan Inhibitor
C8-Ceramide
PKC
        Activator ≥98.0%
N-Desmethyltamoxifen
PKC
        Inhibitor