1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate (Synonyms: Phorbol dibutyrate; PDBu)

Cat. No.: HY-18985 Purity: 98.92%
Handling Instructions

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter.

For research use only. We do not sell to patients.

Phorbol 12,13-dibutyrate Chemical Structure

Phorbol 12,13-dibutyrate Chemical Structure

CAS No. : 37558-16-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 233 In-stock
Estimated Time of Arrival: December 31
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 370 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2].

IC50 & Target

PKC[1]

In Vitro

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (1 MM) activates PKC and inhibited Na/K-ATPase transport activity in OK cells[3].

Molecular Weight

504.61

Formula

C₂₈H₄₀O₈

CAS No.

37558-16-0

SMILES

O=C1C(C)=C[[email protected]@]2([H])[[email protected]]3(O)[[email protected]@]([[email protected]@](C4(C)C)([H])[[email protected]@]4(OC(CCC)=O)[[email protected]](OC(CCC)=O)[[email protected]]3C)([H])C=C(CO)C[[email protected]]12O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (247.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9817 mL 9.9086 mL 19.8173 mL
5 mM 0.3963 mL 1.9817 mL 3.9635 mL
10 mM 0.1982 mL 0.9909 mL 1.9817 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Phorbol 12,13-dibutyrate
Cat. No.:
HY-18985
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