1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKCε Inhibitors

PKCε Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKCι

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Sorry. There is currently no product that acts on isoform PKCε together.

Please try each isoform separately.

PKCε Specific Inhibitors, Activators & Modulators
Product Name PKCε PKC PKCα PKCβ PKCγ PKCδ PKCη PKCζ PKCθ PKCε Selectivity Purity
DCP-LA
PKCε
                Selective Activator ≥98.0%
DCPLA-ME
PKCε
                Selective Activator ≥98.0%
Epsilon-V1-2
PKCε
                Selective Inhibitor
Midostaurin
nPKC-ε, IC50: 1250 nM
 
cPKC-α, IC50: 22 nM
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
  Pan Inhibitor ≥98.0%
Ruboxistaurin
PKCε, IC50: 600 nM
 
PKCα, IC50: 360 nM
PKC-βI, IC50: 4.7 nM
PKC-βII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCη, IC50: 52 nM
    Pan Inhibitor 98.03%
Sotrastaurin
PKCε, Ki: 3.2 nM
 
PKCα, Ki: 0.95 nM
PKCβI, Ki: 0.64 nM
 
PKCδ, Ki: 2.1 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
Pan Inhibitor 99.89%
Rottlerin
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
 
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
  Pan Inhibitor ≥95.0%
Enzastaurin
PKCε, IC50: 110 nM
 
PKCα, IC50: 39 nM
PKCβ, IC50: 6 nM
PKCγ, IC50: 83 nM
        Pan Inhibitor 99.92%
Ingenol Mebutate
PKC-ε, Ki: 0.171 nM
 
PKC-α, Ki: 0.3 nM
PKC-β, Ki: 0.105 nM
PKC-γ, Ki: 0.162 nM
PKC-δ, Ki: 0.376 nM
      Pan Modulator 99.07%
Ro 31-8220 mesylate
PKC-ε, IC50: 24 nM
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
        Pan Inhibitor ≥98.0%
Ruboxistaurin hydrochloride
PKCε, IC50: 600 nM
 
PKCα, IC50: 360 nM
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCη, IC50: 52 nM
    Pan Inhibitor 99.84%
AS2521780
PKCε, IC50: 18 nM
 
PKCα, IC50: 160 nM
   
PKCδ, IC50: 160 nM
   
PKCθ, IC50: 0.48 nM
Pan Inhibitor
Ro 32-0432 hydrochloride
PKCε, IC50: 108.3 nM
 
PKCα, IC50: 9.3 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 30 nM
PKCγ, IC50: 36.5 nM
        Pan Inhibitor
Bisindolylmaleimide VIII acetate
PKC-ε, IC50: 175 nM
Rat Brain PKC, IC50: 158 nM
PKC-α, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKC-γ, IC50: 213 nM
        Pan Inhibitor