2. Epigenetics TGF-beta/Smad
  3. PKC
  4. PKCiota-IN-2 formic

PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 formic also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively.

For research use only. We do not sell to patients.

PKCiota-IN-2 formic Chemical Structure

PKCiota-IN-2 formic Chemical Structure

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5 mg USD 590 In-stock
10 mg USD 760 In-stock
25 mg USD 1512 In-stock
50 mg USD 2424 In-stock
100 mg USD 3880 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PKCiota-IN-2 formic:

PKCiota-IN-2 formic Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

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Description

PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 formic also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively[1].

IC50 & Target[1]

PKCι

2.8 nM (IC50)

PKCα

71 nM (IC50)

PKCε

350 nM (IC50)

Molecular Weight

402.36

Formula

C25H23N5O3
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC2=C(CNCC2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3.OC=O.[0.15]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4853 mL 12.4267 mL 24.8534 mL
5 mM 0.4971 mL 2.4853 mL 4.9707 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4853 mL 12.4267 mL 24.8534 mL 62.1334 mL
5 mM 0.4971 mL 2.4853 mL 4.9707 mL 12.4267 mL
10 mM 0.2485 mL 1.2427 mL 2.4853 mL 6.2133 mL
15 mM 0.1657 mL 0.8284 mL 1.6569 mL 4.1422 mL
20 mM 0.1243 mL 0.6213 mL 1.2427 mL 3.1067 mL
25 mM 0.0994 mL 0.4971 mL 0.9941 mL 2.4853 mL
30 mM 0.0828 mL 0.4142 mL 0.8284 mL 2.0711 mL
40 mM 0.0621 mL 0.3107 mL 0.6213 mL 1.5533 mL
50 mM 0.0497 mL 0.2485 mL 0.4971 mL 1.2427 mL
60 mM 0.0414 mL 0.2071 mL 0.4142 mL 1.0356 mL
80 mM 0.0311 mL 0.1553 mL 0.3107 mL 0.7767 mL
100 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.6213 mL
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PKCiota-IN-2 formic Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKCiota-IN-2PKCProtein kinase CPKCiotaPKC-αPKC-εInhibitorinhibitorinhibit

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