PKCiota-IN-2 formic
Based on 1 Customer Validation
PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 formic also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.04%
- Formula: C25H23N5O3
- Molecular Weight:402.36
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Biological Activity
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PKCι 2.8 nM (IC50) |
PKCα 71 nM (IC50) |
PKCε 350 nM (IC50) |
Chemical Information
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Appearance Solid
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Molecular Weight 402.36
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Formula C25H23N5O3
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Color Light yellow to yellow
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SMILES
COC1=CC2=C(CNCC2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3.OC=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (248.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4853 mL | 12.4267 mL | 24.8534 mL | 62.1334 mL |
| 5 mM | 0.4971 mL | 2.4853 mL | 4.9707 mL | 12.4267 mL | |
| 10 mM | 0.2485 mL | 1.2427 mL | 2.4853 mL | 6.2133 mL | |
| 15 mM | 0.1657 mL | 0.8284 mL | 1.6569 mL | 4.1422 mL | |
| 20 mM | 0.1243 mL | 0.6213 mL | 1.2427 mL | 3.1067 mL | |
| 25 mM | 0.0994 mL | 0.4971 mL | 0.9941 mL | 2.4853 mL | |
| 30 mM | 0.0828 mL | 0.4142 mL | 0.8284 mL | 2.0711 mL | |
| 40 mM | 0.0621 mL | 0.3107 mL | 0.6213 mL | 1.5533 mL | |
| 50 mM | 0.0497 mL | 0.2485 mL | 0.4971 mL | 1.2427 mL | |
| 60 mM | 0.0414 mL | 0.2071 mL | 0.4142 mL | 1.0356 mL | |
| 80 mM | 0.0311 mL | 0.1553 mL | 0.3107 mL | 0.7767 mL | |
| 100 mM | 0.0249 mL | 0.1243 mL | 0.2485 mL | 0.6213 mL |