PKCiota-IN-2
PKCiota-IN-2 (Compound 49) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2230055-52-2
- Formula: C24H21N5O
- Molecular Weight:395.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
PKCι 2.8 nM (IC50) |
PKCα 71 nM (IC50) |
PKCε 350 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCCLM3 | GI50 |
3 μM
Compound: 49
|
Antiproliferative activity against human HCCLM3 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HCCLM3 cells after 72 hrs by CellTiter-Glo assay
|
[PMID: 29688013] |
| Huh-7 | GI50 |
1.4 μM
Compound: 49
|
Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter-Glo assay
|
[PMID: 29688013] |
Chemical Information
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CAS No. 2230055-52-2
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Molecular Weight 395.46
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Formula C24H21N5O
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SMILES
COC1=CC2=C(CNCC2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)