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Referencia número: HY-122858

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PKCiota-IN-2

Name: PKCiota-IN-2
Brand: MedChemExpress
SKU: HY-122858
Availability: PreOrder

PKCiota-IN-2 (Compound 49) is a potent PKCiota (PKC-ι) inhibitor with an IC₅₀ of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC₅₀s of 71 nM and 350 nM, respectively.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (PKCiota-IN-2 formic) usually boasts enhanced water solubility and stability.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2230055-52-2
Fòrmula: C₂₄H₂₁N₅O
Peso molecular:395.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PKCiota-IN-2 Chemical Structure

No. CAS: 2230055-52-2

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Other In-stock Forms of PKCiota-IN-2

PKCiota-IN-2 formic

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

PKCι

2.8 nM (IC₅₀)

PKCα

71 nM (IC₅₀)

PKCε

350 nM (IC₅₀)

Ver todos los productos específicos de isoformas PKC :

Cellular Effect

Cell Line	Type	Value	Description	References
HCCLM3	GI₅₀	3 μM Compound: 49	Antiproliferative activity against human HCCLM3 cells after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human HCCLM3 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29688013]
Huh-7	GI₅₀	1.4 μM Compound: 49	Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29688013]

Chemical Information

No. CAS 2230055-52-2
Peso molecular 395.46
Fòrmula C₂₄H₂₁N₅O
SMILES

COC1=CC2=C(CNCC2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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