1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKCβ Inhibitors

PKCβ Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

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Sorry. There is currently no product that acts on isoform PKCβ together.

Please try each isoform separately.

PKCβ Specific Inhibitors
Product Name PKCβ PKC PKCα PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCβ Selectivity Purity
Ruboxistaurin hydrochloride
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
 
PKCα, IC50: 360 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
    Selective Inhibitor 98.88%
Midostaurin
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
 
cPKC-α, IC50: 22 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 16 nM
aPKC-ζ, IC50: 465000 nM
  Pan Inhibitor 99.85%
Bisindolylmaleimide I
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKCγ, IC50: 20 nM
          Pan Inhibitor 98.04%
Sotrastaurin
PKCβI, Ki: 0.64 nM
 
PKCα, Ki: 0.95 nM
 
PKCδ, Ki: 2.1 nM
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
Pan Inhibitor 99.83%
Ro 31-8220 mesylate
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-γ, IC50: 27 nM
 
PKC-ε, IC50: 24 nM
      Pan Inhibitor 99.28%
Rottlerin
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
 
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
  Pan Inhibitor >95.0%