425637-18-9
425637-18-9
Chemical Structure
Sotrastaurin
Synonym(s): AEB071
- CAS No.: 425637-18-9
- Formula:C25H22N6O2
- Molecular Weight:438.48
IUPAC Name: 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
InChIKey: OAVGBZOFDPFGPJ-UHFFFAOYSA-N
SMILES: O=C(C(C1=C2C=CC=CC2=NC(N3CCN(C)CC3)=N1)=C4C5=CNC6=C5C=CC=C6)NC4=O
Biological Activity: Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sotrastaurin | 99.79% | Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively. | ||||||||||||||||||||
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Sotrastaurin (Standard) | ≥98% | Sotrastaurin (Standard) is the analytical standard of Sotrastaurin. This product is intended for research and analytical applications. Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.95
HY-10540Sotrastaurin acetate -
Similarity Score 0.62
HY-177283PKC-IN-7 -
Similarity Score 0.61
HY-108604Bisindolylmaleimide II -
Similarity Score 0.60
HY-137045Bisindolylmaleimide VII -
Similarity Score 0.60
HY-108254RBisindolylmaleimide IV (Standard) -
Similarity Score 0.58
HY-112454Bisindolylmaleimide III hydrochloride -
Similarity Score 0.58
HY-117393Bisindolylmaleimide III -
Similarity Score 0.58
HY-13867ARBisindolylmaleimide I hydrochloride (Standard) -
Similarity Score 0.58
HY-13867RBisindolylmaleimide I (Standard) -
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