1. Epigenetics
    TGF-beta/Smad
  2. PKC

(-)-Indolactam V (Synonyms: Indolactam V)

Cat. No.: HY-12307 Purity: 99.18%
Handling Instructions

(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

For research use only. We do not sell to patients.

(-)-Indolactam V Chemical Structure

(-)-Indolactam V Chemical Structure

CAS No. : 90365-57-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 438 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 660 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
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50 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

IC50 & Target

Ki: 3.36 nM (η-CRD2 (PKCη surrogate peptide)), 1.03 μM (γ-CRD2 (PKCγ surrogate peptide))[1]
Kd: 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B)[2]

In Vitro

(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and has antitumor activity[1]. (-)-Indolactam V shows Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), respectively[2]. (-)-Indolactam V (20 nM-5 μM) dose-dependently affects multiple hESC lines, such as HUES 2, 4 and 8. (-)-Indolactam V also increases the mRNA levels of Pdx1, HNF6, PTF1A, SOX9, HB9 and PROX1. In addition, (-)-Indolactam V (300 nM) functions in both mouse and human cells and confirms that some signals for pancreatic development[3].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.3181 mL 16.5904 mL 33.1807 mL
5 mM 0.6636 mL 3.3181 mL 6.6361 mL
10 mM 0.3318 mL 1.6590 mL 3.3181 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay
[3]

For induced differentiation to endocrine or exocrine cells, the (-)-Indolactam V (300 nM)-treated populations are cultured in DMEM/F12 supplemented with 1 N2, 2 mg/mL albumin fraction V and 10 ng/mL bovine FGF for the first 4 d. 10 mM nicotinamide is then added and maintained for an additional 8 d, changing the medium every 3 d[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

301.38

Formula

C₁₇H₂₃N₃O₂

CAS No.

90365-57-4

SMILES

CC(C)[[email protected]@H](C1=O)N(C)C2=C3C(NC=C3C[[email protected]](N1)CO)=CC=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
(-)-Indolactam V
Cat. No.:
HY-12307
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