1. Epigenetics
    TGF-beta/Smad
  2. PKC

(-)-Indolactam V (Synonyms: Indolactam V)

Cat. No.: HY-12307 Purity: 99.18%
Handling Instructions

(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

For research use only. We do not sell to patients.

(-)-Indolactam V Chemical Structure

(-)-Indolactam V Chemical Structure

CAS No. : 90365-57-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 438 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 660 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

IC50 & Target[1][2]

PKCη-CRD2

3.36 nM (Ki)

PKCη-C1B

5.5 nM (Kd)

PKCε-C1B

7.7 nM (Kd)

PKCδ-C1B

8.3 nM (Kd)

PKCθ-C1B

8.7 nM (Kd)

PKCβ-C1A-long

18.9 nM (Kd)

PKCα-C1A-long

20.8 nM (Kd)

PKCβ-C1B

137 nM (Kd)

PKCγ-C1A

138 nM (Kd)

PKCγ-C1B

213 nM (Kd)

PKCγ-CRD2

1030 nM (Ki)

PKCδ-C1A

1900 nM (Kd)

PKCη-C1A

3770 nM (Kd)

PKCα-C1B-long

4000 nM (Kd)

PKCε-C1A

4110 nM (Kd)

In Vitro

(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and has antitumor activity[1]. (-)-Indolactam V shows Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), respectively[2]. (-)-Indolactam V (20 nM-5 μM) dose-dependently affects multiple hESC lines, such as HUES 2, 4 and 8. (-)-Indolactam V also increases the mRNA levels of Pdx1, HNF6, PTF1A, SOX9, HB9 and PROX1. In addition, (-)-Indolactam V (300 nM) functions in both mouse and human cells and confirms that some signals for pancreatic development[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3181 mL 16.5904 mL 33.1807 mL
5 mM 0.6636 mL 3.3181 mL 6.6361 mL
10 mM 0.3318 mL 1.6590 mL 3.3181 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[3]

For induced differentiation to endocrine or exocrine cells, the (-)-Indolactam V (300 nM)-treated populations are cultured in DMEM/F12 supplemented with 1 N2, 2 mg/mL albumin fraction V and 10 ng/mL bovine FGF for the first 4 d. 10 mM nicotinamide is then added and maintained for an additional 8 d, changing the medium every 3 d[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

301.38

Formula

C₁₇H₂₃N₃O₂

CAS No.

90365-57-4

SMILES

CC(C)[[email protected]@H](C1=O)N(C)C2=C3C(NC=C3C[[email protected]](N1)CO)=CC=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(-)-Indolactam V
Cat. No.:
HY-12307
Quantity:

(-)-Indolactam V

Cat. No.: HY-12307