1. Vitamin D Related/Nuclear Receptor Membrane Transporter/Ion Channel
  2. Estrogen Receptor/ERR Potassium Channel
  3. Endoxifen (Z-isomer)

Endoxifen Z-isomer is the most important Tamoxifen metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM.

For research use only. We do not sell to patients.

Endoxifen (Z-isomer) Chemical Structure

Endoxifen (Z-isomer) Chemical Structure

CAS No. : 112093-28-4

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Based on 2 publication(s) in Google Scholar

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Description

Endoxifen Z-isomer is the most important Tamoxifen metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM.

Molecular Weight

373.49

Formula

C25H27NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Endoxifen (Z-isomer)
Cat. No.:
HY-18719
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