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  2. Estrogen Receptor/ERR

Endoxifen E-isomer hydrochloride (Synonyms: E-Endoxifen hydrochloride)

Cat. No.: HY-18719C Purity: 98.20%
Handling Instructions

Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

For research use only. We do not sell to patients.

Endoxifen E-isomer hydrochloride Chemical Structure

Endoxifen E-isomer hydrochloride Chemical Structure

CAS No. : 1197194-61-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 396 In-stock
Estimated Time of Arrival: December 31
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 Get quote
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of Endoxifen E-isomer hydrochloride:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). Target: Estrogen Receptor/ERR Endoxifen is considered a prodrug, since it has a much higher potency for the estrogen receptor than its parent drug. Endoxifen inhibits the hERG channel protein trafficking to the plasma membrane in a concentration-dependent manner with Endoxifen being more potent than Tamoxifen. [1] Endoxifen is also shown to be a more potent inhibitor of estrogen target genes when ERβ is expressed. Additionally, low concentrations of Endoxifen observed in Tamoxifen treated patients with deficient CYP2D6 activity (20 to 40 nM) markedly inhibit estrogen-induced cell proliferation rates in the presence of ERβ, whereas much higher Endoxifen concentrations are needed when ERβ is absent.[2]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (73.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4393 mL 12.1966 mL 24.3932 mL
5 mM 0.4879 mL 2.4393 mL 4.8786 mL
10 mM 0.2439 mL 1.2197 mL 2.4393 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

409.95

Formula

C₂₅H₂₈ClNO₂

CAS No.

1197194-61-8

SMILES

OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl.[E]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Endoxifen E-isomer hydrochloride
Cat. No.:
HY-18719C
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Endoxifen E-isomer hydrochloride

Cat. No.: HY-18719C