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  3. Endoxifen E-isomer hydrochloride

Endoxifen E-isomer hydrochloride (Synonyms: E-Endoxifen hydrochloride)

Cat. No.: HY-18719C Purity: 98.20%
Handling Instructions

Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer drug substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects.

For research use only. We do not sell to patients.

Endoxifen E-isomer hydrochloride Chemical Structure

Endoxifen E-isomer hydrochloride Chemical Structure

CAS No. : 1197194-61-8

Size Price Stock
Solution
10 mM * 1 mL in DMSO USD 234 Ask For Quote & Lead Time
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 234 Ask For Quote & Lead Time
Solid
1 mg USD 65 Ask For Quote & Lead Time
5 mg USD 260 Ask For Quote & Lead Time
10 mg USD 380 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Other In-stock Forms of Endoxifen E-isomer hydrochloride:

Other Forms of Endoxifen E-isomer hydrochloride:

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Description

Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer drug substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects[1][2].

In Vitro

Endoxifen E-isomer (1-1000 nM; 12 h) inhibits PGR gene expression in E2-induced MCF-7 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

409.95

Formula

C25H28ClNO2

CAS No.
SMILES

OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl.[E]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (73.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4393 mL 12.1966 mL 24.3932 mL
5 mM 0.4879 mL 2.4393 mL 4.8786 mL
10 mM 0.2439 mL 1.2197 mL 2.4393 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.10 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Endoxifen E-isomer hydrochloride
Cat. No.:
HY-18719C
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