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  3. Letrozole

Letrozole (Synonyms: CGS 20267)

Cat. No.: HY-14248 Purity: 99.92%
Handling Instructions

Letrozole is an aromatase inhibitor with an IC50 of 1-13 nM.

For research use only. We do not sell to patients.

Letrozole Chemical Structure

Letrozole Chemical Structure

CAS No. : 112809-51-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
200 mg USD 77 In-stock
Estimated Time of Arrival: December 31
500 mg USD 91 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Letrozole purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Jun;15(6):5269-5274.

    Detection of the effects of Letrozole and the MAPK pathway on the proliferation of GC-1 spg cells by BrdU. MAPK, mitogen-activated protein kinase; spg, spermatogonia; BrdU, bromodeoxyuridine.

    Letrozole purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Jun;15(6):5269-5274.

    Letrozole significantly increases the protein levels of Ras/ERK1/c-Myc in the classical MAPK pathway.
    • Biological Activity

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    • References

    • Customer Review

    Description

    Letrozole is an aromatase inhibitor with an IC50 of 1-13 nM.

    Clinical Trial
    Molecular Weight

    285.30

    Formula

    C₁₇H₁₁N₅

    CAS No.

    112809-51-5

    SMILES

    N#CC1=CC=C(C(N2C=NC=N2)C3=CC=C(C#N)C=C3)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (175.25 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5051 mL 17.5254 mL 35.0508 mL
    5 mM 0.7010 mL 3.5051 mL 7.0102 mL
    10 mM 0.3505 mL 1.7525 mL 3.5051 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.92%

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    Product Name:
    Letrozole
    Cat. No.:
    HY-14248
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