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  3. Letrozole

Letrozole (Synonyms: CGS 20267)

Cat. No.: HY-14248 Purity: 99.92%
Handling Instructions

Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer.

For research use only. We do not sell to patients.

Letrozole Chemical Structure

Letrozole Chemical Structure

CAS No. : 112809-51-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
200 mg USD 77 In-stock
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500 mg USD 91 In-stock
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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Letrozole purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Jun;15(6):5269-5274.

    Detection of the effects of Letrozole and the MAPK pathway on the proliferation of GC-1 spg cells by BrdU. MAPK, mitogen-activated protein kinase; spg, spermatogonia; BrdU, bromodeoxyuridine.

    Letrozole purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Jun;15(6):5269-5274.

    Letrozole significantly increases the protein levels of Ras/ERK1/c-Myc in the classical MAPK pathway.
    • Biological Activity

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    • References

    • Customer Review

    Description

    Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].

    IC50 & Target

    IC50: 11.5 nM (aromatase)[1]

    In Vitro

    Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner[2].
    Letrozole (10 nM) significantly suppresses the stimulatory effects of 4-androstene-3,17-dione or testosterone on MCF-7 cell proliferation[2].
    Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells[2].

    Cell Viability Assay[2]

    Cell Line: MCF-7 cells
    Concentration: 0.1, 1, 10, 100 nM
    Incubation Time: 24, 48, 96 hours
    Result: Inhibited cells growth in a dose- and time-dependent manner.
    In Vivo

    Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats[3].

    Animal Model: Adult female rats bearing mammary tumors[3]
    Dosage: 3, 10, 30, 100, 300 μg/kg
    Administration: Oral gavage once daily for 6 weeks
    Result: Induced complete regression of mammary tumors, with an ED50 of 10-30 μg/kg/day.
    Clinical Trial
    Molecular Weight

    285.30

    Formula

    C₁₇H₁₁N₅

    CAS No.

    112809-51-5

    SMILES

    N#CC1=CC=C(C(N2C=NC=N2)C3=CC=C(C#N)C=C3)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (175.25 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5051 mL 17.5254 mL 35.0508 mL
    5 mM 0.7010 mL 3.5051 mL 7.0102 mL
    10 mM 0.3505 mL 1.7525 mL 3.5051 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.92%

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    Keywords:

    LetrozoleCGS 20267CGS20267CGS-20267AromataseAutophagyaromataseestrogenbreastcancerInhibitorinhibitorinhibit

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    Cat. No.:
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