1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI3K
  4. Vps34 Inhibitors

Vps34 Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

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Sorry. There is currently no product that acts on isoform Vps34 together.

Please try each isoform separately.

Vps34 Specific Inhibitors
Product Name Vps34 PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 Selectivity Purity
Vps34-PIK-III
Vps34, IC50: 18 nM
PI(3)Kα, IC50: 3.96 μM
 
PI(3)Kγ, IC50: 3.04 μM
PI(3)Kδ, IC50: 1.2 μM
      Selective Inhibitor 99.06%
Vps34-IN-2
Vps34, IC50: 2 nM
              Selective Inhibitor 99.75%
3-Methyladenine
Vps34, IC50: 25 μM (Cell Assay)
   
PtdIns3Kγ, IC50: 60 μM (Cell Assay)
        Pan Inhibitor 99.84%
Buparlisib
Vps34, IC50: 2.4 μM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
      Pan Inhibitor 99.90%
Idelalisib
hVps34, IC50: 978 nM
p110α, IC50: 820 nM
p110β, IC50: 565 nM
p110γ, IC50: 89 nM
p110δ, IC50: 2.5 nM
      Pan Inhibitor 99.98%
PI-103
hsVPS34, IC50: 2.3 μM
p110α, IC50: 8 nM
p110β, IC50: 88 nM
p110γ, IC50: 150 nM
p110δ, IC50: 48 nM
PI3KC2α, IC50: 1 μM
PI3KC2β, IC50: 26 nM
  Pan Inhibitor 99.86%
Bimiralisib
Vps34, IC50: 6486 nM
PI3Kα, IC50: 33 nM
PI3Kα-H1047R, IC50: 36 nM
PI3Kα-E545K, IC50: 136 nM
PI3Kα-E542K, IC50: 63 nM
PI3Kβ, IC50: 661 nM
PI3Kγ, IC50: 708 nM
PI3Kδ, IC50: 451 nM
      Pan Inhibitor 98.90%
PIK-75
hsVPS34, IC50: 2.6 μM
p110α, IC50: 5.8 nM
p110β, IC50: 1.3 μM
p110γ, IC50: 76 nM
p110δ, IC50: 510 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
  Pan Inhibitor 99.91%
PIK-93
hsVPS34, IC50: 320 nM
p110α, IC50: 39 nM
p110β, IC50: 590 nM
p110γ, IC50: 16 nM
p110δ, IC50: 120 nM
PI3KC2α, IC50: 16 μM
PI3KC2β, IC50: 140 nM
  Pan Inhibitor 99.13%
Buparlisib Hydrochloride
Vps34, IC50: 2.4 μM
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
      Pan Inhibitor 98.01%
Pilaralisib
Vps34, IC50: 6974 nM
PI3Kα, IC50: 39 nM
PI3Kβ, IC50: 383 nM
PI3Kγ, IC50: 23 nM
PI3Kδ, IC50: 36 nM
      Pan Inhibitor 98.35%
Acalisib
hVps34, IC50: 12682 nM
p110α, IC50: 5441 nM
p110β, IC50: 3377 nM
p110γ, IC50: 1389 nM
p110δ, IC50: 12.7 nM
      Pan Inhibitor 99.98%
SAR-260301
Vps34, IC50: 183 nM
PI3Kα, IC50: 1539 nM
PI3Kβ, IC50: 23 nM
PI3Kγ, IC50: 10000 nM
PI3Kδ, IC50: 468 nM
   
PI3KC2γ, IC50: 3812 nM
Pan Inhibitor 99.74%
PIK-90
hsVPS34, IC50: 830 nM
p110α, IC50: 11 nM
p110β, IC50: 350 nM
p110γ, IC50: 18 nM
p110δ, IC50: 58 nM
PI3KC2α, IC50: 47 nM
PI3KC2β, IC50: 64 nM
  Pan Inhibitor 99.06%
VS-5584
Vps34, IC50: 7470 nM
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 68 nM
PI3Kγ, IC50: 25 nM
PI3Kδ, IC50: 42 nM
      Pan Inhibitor 98.01%
CHMFL-PI3KD-317
Vps34, IC50: 1801.7 nM
PI3Kα, IC50: 62.6 nM
PI3Kβ, IC50: 284 nM
PI3Kγ, IC50: 202.7 nM
PI3Kδ, IC50: 6 nM
 
PIK3C2B, IC50: 882.3 nM
  Pan Inhibitor