1383716-40-2
1383716-40-2
Chemical Structure
Vps34-PIK-III
- CAS No.: 1383716-40-2
- Formula:C17H17N7
- Molecular Weight:319.36
IUPAC Name: 4'-(cyclopropylmethyl)-N2-(pyridin-4-yl)-[4,5'-bipyrimidine]-2,2'-diamine
InChIKey: XXSDLQLNIVFIJI-UHFFFAOYSA-N
SMILES: NC1=NC=C(C2=CC=NC(NC3=CC=NC=C3)=N2)C(CC4CC4)=N1
Biological Activity: Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC50=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vps34-PIK-III | 99.63% | Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC50=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.79
HY-123058Vps34-IN-4 -
Similarity Score 0.68
HY-12795Vps34-IN-1 -
Similarity Score 0.52
HY-112255J9 -
Similarity Score 0.51
HY-W013852PKC-IN-6 -
Similarity Score 0.50
HY-111295LAS38096 -
Similarity Score 0.50
HY-128491UNC10112785 -
Similarity Score 0.49
HY-183529Antitrypanosomal agent 31 -
Similarity Score 0.49
HY-11009CGP60474 -
Similarity Score 0.48
HY-757804-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoic acid -
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References
- [1]. Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6. [Content Brief]
- [2]. Liu F, et al. PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor. Cell Death Dis. 2020 Jun 8;11(6):427. [Content Brief]
- [3]. Dowdle WE, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014 Nov;16(11):1069-79. [Content Brief]
