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Cat. No.: HY-128491

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UNC10112785

UNC10112785 is a serine/threonine kinase inhibitor with a human GSK-3β IC₅₀ of 0.031 μM, human CDK-2 IC₅₀ of 0.016 μM, and human CDK-4 IC₅₀ of 1.99 μM. UNC10112785 can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

CAS No.: 748142-06-5
Formula: C₁₉H₁₈N₆
Molecular Weight:330.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

UNC10112785 Chemical Structure

CAS No.: 748142-06-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

CDK2

0.016 μM (IC₅₀)

GSK-3

0.031 μM (IC₅₀)

CDK4

1.99 μM (IC₅₀)

All GSK-3 Isoforms :

All CDK Isoforms :

In Vitro

UNC10112785 (compound 22) (40 min) inhibits human GSK-3β (IC₅₀ = 0.031 μM), CDK-2 (IC₅₀ = 0.016 μM) and CDK-4 (IC₅₀ = 1.99 μM) in in vitro enzymatic activity assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 748142-06-5
Molecular Weight 330.40
Formula C₁₉H₁₈N₆
SMILES

N1=CC=C(N=C1NC2=CC=C(C=C2)C(C)C)C=3C=NN4N=CC=CC34
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tavares FX, et al. N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy. J Med Chem. 2004;47(19):4716-4730. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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UNC10112785

All GSK-3 Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

UNC10112785 Related Classifications

HY-128491 Related Classifications