CDK1 Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

CDK1 Specific Inhibitors

Product Name	CDK1	CDK2	CDK3	CDK4	CDK5	CDK6	CDK7	CDK8	CDK9	CDK14	CDK16	CLK	CDK1 Selectivity	Purity
PF 477736	CDK1, Ki: 9.9 μM												Selective Inhibitor	99.21%
Ro-3306	CDK1, Ki: 20 nM CDK1/cyclinB1, Ki: 35 nM CDK1/cyclin A, Ki: 110 nM	CDK2/cyclinE, Ki: 340 nM											Selective Inhibitor	98.54%
Cucurbitacin E	cyclin B1/CDC2												Selective Inhibitor	99.92%
Abemaciclib	CDK1/cyclinB1, IC₅₀: 1627 nM	CDK2/cyclinE, IC₅₀: 504 nM		Cdk4/cyclin D1, IC₅₀: 2 nM	CDK5/p35, IC₅₀: 287 nM Cdk5/p25, IC₅₀: 355 nM	CDK6/cyclinD1, IC₅₀: 10 nM	CDK7/Mat1/cyclinH1, IC₅₀: 3910 nM		CDK9/cyclinT1, IC₅₀: 57 nM				Pan Inhibitor	99.69%
Abemaciclib methanesulfonate	CDK1/cyclinB1, IC₅₀: 1627 nM	CDK2/cyclinE, IC₅₀: 504 nM		Cdk4/cyclin D1, IC₅₀: 2 nM	Cdk5/p25, IC₅₀: 355 nM CDK5/p35, IC₅₀: 287 nM	CDK6/cyclinD1, IC₅₀: 10 nM	CDK7/Mat1/cyclinH1, IC₅₀: 3910 nM		CDK9/cyclinT1, IC₅₀: 57 nM				Pan Inhibitor	99.95%
Dinaciclib	CDK1, IC₅₀: 3 nM	CDK2, IC₅₀: 1 nM			CDK5, IC₅₀: 1 nM				CDK9, IC₅₀: 4 nM				Pan Inhibitor	99.73%
Flavopiridol	CDK1/Cyc B1, IC₅₀: 30 nM	CDK2/Cyc E, IC₅₀: 170 nM		CDK4/Cyc D1, IC₅₀: 100 nM									Pan Inhibitor	99.72%
Seliciclib	cdc2/cyclin B, IC₅₀: 0.65 μM	cdk2/cyclin A, IC₅₀: 0.7 μM Cdk2/cyclin E2, IC₅₀: 0.7 μM			CDK5/p35, IC₅₀: 0.16 μM								Pan Inhibitor	99.94%
SNS-032	CDK1, IC₅₀: 480 nM	CDK2, IC₅₀: 38 nM		CDK4, IC₅₀: 925 nM			CDK7, IC₅₀: 62 nM		CDK9, IC₅₀: 4 nM				Pan Inhibitor	98.50%
AZD-5438	cdk1-cyclin B1, IC₅₀: 16 nM	cdk2-cyclin E, IC₅₀: 6 nM cdk2-cyclin A, IC₅₀: 45 nM		cdk4-cyclin D1, IC₅₀: 449 nM	cdk5-p25, IC₅₀: 14 nM	cdk6-cyclin D3, IC₅₀: 21 nM	cdk7-cyclin H, IC₅₀: 821 nM		cdk9-cyclin T, IC₅₀: 20 nM				Pan Inhibitor	99.37%
AT7519	Cdk1/cyclin B, IC₅₀: 210 nM	cdk2/cyclin A, IC₅₀: 47 nM		Cdk4/cyclin D1, IC₅₀: 100 nM	CDK5/p35, IC₅₀: 13 nM	cdk6/cyclin D3, IC₅₀: 170 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2400 nM		CDK9/Cyclin T, IC₅₀: 10 nM				Pan Inhibitor	99.40%
GSK 3 Inhibitor IX	Cdk1/cyclin B, IC₅₀: 320 nM	cdk2/cyclin A, IC₅₀: 300 nM		Cdk4/cyclin D1, IC₅₀: 10 μM	CDK5/p35, IC₅₀: 80 nM								Pan Inhibitor	99.66%
JNJ-7706621	Cdk1/cyclin B, IC₅₀: 9 nM	CDK2/cyclinE, IC₅₀: 3 nM cdk2/cyclin A, IC₅₀: 4 nM	CDK3/Cyclin E, IC₅₀: 58 nM	Cdk4/cyclin D1, IC₅₀: 253 nM		CDK6/cyclinD1, IC₅₀: 175 nM							Pan Inhibitor	99.96%
Samuraciclib hydrochloride	CDK1/cyc A, IC₅₀: 1.8 μM	cdk2/cyclin A, IC₅₀: 578 nM		CDK4/Cyc D1, IC₅₀: 49 μM	CDK5/p35NCK, IC₅₀: 9.4 μM	CDK6/cycD1, IC₅₀: 34 μM	CDK7/cyclin H, IC₅₀: 41 nM		CDK9/CycT1, IC₅₀: 1.2 μM				Pan Inhibitor	99.98%
Flavopiridol Hydrochloride	CDK1/Cyc B1, IC₅₀: 30 nM	CDK2/Cyc E, IC₅₀: 170 nM		CDK4/Cyc D1, IC₅₀: 100 nM									Pan Inhibitor	99.90%
Kenpaullone	Cdk1/cyclin B, IC₅₀: 0.4 μM	cdk2/cyclin A, IC₅₀: 0.68 μM CDK2/cyclinE, IC₅₀: 7.5 μM			CDK5/p35, IC₅₀: 0.85 μM								Pan Inhibitor	>97.0%
CVT-313	Cdk1/cyclin B, IC₅₀: 4.2 μM	cdk2/cyclin A, IC₅₀: 0.5 μM		Cdk4/cyclin D1, IC₅₀: 215 μM									Pan Inhibitor	99.76%
Milciclib	cyclin B/CDK1, IC₅₀: 398 nM	cyclin A/CDK2, IC₅₀: 45 nM cyclin E/CDK2, IC₅₀: 363 nM		cyclin D1/CDK4, IC₅₀: 160 nM			cyclin H/CDK7, IC₅₀: 150 nM						Pan Inhibitor	99.92%
THZ2	CDK1, IC₅₀: 96.9 nM	CDK2, IC₅₀: 222 nM			CDK5, IC₅₀: 134 nM		CDK7, IC₅₀: 13.9 nM	CDK8, IC₅₀: 6830 nM	CDK9, IC₅₀: 194 nM				Pan Inhibitor	99.62%
CGP60474	CDK1-Cyclin B, IC₅₀: 26 nM	CDK2/cyclinE, IC₅₀: 3 nM cdk2/cyclin A, IC₅₀: 4 nM		CDK4/cyclin D, IC₅₀: 216 nM	Cdk5/p25, IC₅₀: 10 nM		CDK7/cyclin H, IC₅₀: 200 nM		CDK9/cycT, IC₅₀: 13 nM				Pan Inhibitor	98.70%
BMS-265246	CDK1/cycB, IC₅₀: 6 nM	CDK2/Cyc E, IC₅₀: 9 nM		CDK4/cycD, IC₅₀: 230 nM									Pan Inhibitor	99.28%
LDC000067	cdk1-cyclin B1, IC₅₀: 5513 nM	cdk2-cyclin A, IC₅₀: 2441 nM		cdk4-cyclin D1, IC₅₀: 9242 nM					CDK9- Cyclin T1, IC₅₀: 44 nM				Pan Inhibitor	98.58%
R547	Cdk1/cyclin B, Ki: 2 nM Cdk1/cyclin B, IC₅₀: 0.2 nM	CDK2/cyclinE, Ki: 3 nM cdk2/cyclin A, IC₅₀: 0.1 nM CDK2/cyclinE, IC₅₀: 0.4 nM	CDK3/Cyclin E, IC₅₀: 0.8 nM	CDK4/cyclin D, Ki: 1 nM	CDK5/p35, IC₅₀: 0.1 nM	cdk6/cyclin D3, IC₅₀: 4 nM	CDK7/cyclin H, IC₅₀: 171 nM						Pan Inhibitor	99.66%
Roniciclib	Cdk1/cyclin B, IC₅₀: 7 nM	CDK2/cyclinE, IC₅₀: 9 nM		CDK4/cyclin D, IC₅₀: 11 nM			CDK7/Cyclin H/MAT1, IC₅₀: 25 nM		CDK9/cyclinT1, IC₅₀: 5 nM				Pan Inhibitor	98.89%
PHA-767491 hydrochloride	CDK1, IC₅₀: 250 nM	CDK2, IC₅₀: 240 nM			CDK5, IC₅₀: 460 nM				CDK9, IC₅₀: 34 nM				Pan Inhibitor	99.91%
Purvalanol A	cdc2-cyclin B, IC₅₀: 4 nM	cdk2-cyclin E, IC₅₀: 35 nM cdk2-cyclin A, IC₅₀: 70 nM		cdk4-cyclin D1, IC₅₀: 850 nM	cdk5-p35, IC₅₀: 75 nM								Pan Inhibitor	99.11%
PHA-793887	Cdk1/cyclin B, IC₅₀: 60 nM	cdk2/cyclin A, IC₅₀: 8 nM CDK2/cyclinE, IC₅₀: 8 nM		Cdk4/cyclin D1, IC₅₀: 62 nM	Cdk5/p25, IC₅₀: 5 nM		CDK7/cyclin H, IC₅₀: 10 nM		CDK9/cyclinT1, IC₅₀: 138 nM				Pan Inhibitor	99.95%
Atuveciclib	CDK1/CycB(h), IC₅₀: 1100 nM	CDK2/CycE(h), IC₅₀: 1000 nM	CDK3/CycE(h), IC₅₀: 890 nM		CDK5/p35(h), IC₅₀: 1600 nM				CDK9/CycT1, IC₅₀: 13 nM CDK9/CycT1(h), IC₅₀: 6 nM				Pan Inhibitor	99.20%
CDK2-IN-4	Cdk1/cyclin B, IC₅₀: 86 μM	cdk2/cyclin A, IC₅₀: 44 nM											Pan Inhibitor	>97.0%
SU9516	CDK1, IC₅₀: 40 nM	CDK2, IC₅₀: 22 nM		CDK4, IC₅₀: 200 nM									Pan Inhibitor	99.83%
(R)-CR8 trihydrochloride	CDK1/cyclinB1, IC₅₀: 0.09 μM	cdk2/cyclin A, IC₅₀: 0.072 μM CDK2/cyclinE, IC₅₀: 0.041 μM			Cdk5/p25, IC₅₀: 0.11 μM		CDK7/cyclin H, IC₅₀: 1.1 μM		CDK9/Cyclin T, IC₅₀: 0.18 μM				Pan Inhibitor	99.02%
NG 52	cdc2-cyclin B, IC₅₀: 0.34 μM				Pho85p, IC₅₀: 2 nM								Pan Inhibitor	99.97%
Lerociclib dihydrochloride	CDK1/cyclinB1, IC₅₀: 2.4 μM	cdk2/cyclin A, IC₅₀: 1.5 μM CDK2/cyclinE, IC₅₀: 3.6 μM		Cdk4/cyclin D1, IC₅₀: 1 nM	CDK5/p35, IC₅₀: 832 nM Cdk5/p25, IC₅₀: 1.2 μM	cdk6/cyclin D3, IC₅₀: 2 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2.4 μM		CDK9/Cyclin T, IC₅₀: 28 nM				Pan Inhibitor	98.45%
CDKI-73	CDK1, IC₅₀: 8.17 nM CDK1, Ki: 4 nM	CDK2, IC₅₀: 3.27 nM CDK2, Ki: 3 nM		CDK4, IC₅₀: 8.18 nM		CDK6, IC₅₀: 37.68 nM	CDK7, IC₅₀: 134.26 nM CDK7, Ki: 91 nM		CDK9, IC₅₀: 5.78 nM CDK9, Ki: 4 nM				Pan Inhibitor	99.58%
AT7519 Hydrochloride	Cdk1/cyclin B, IC₅₀: 210 nM	cdk2/cyclin A, IC₅₀: 47 nM		Cdk4/cyclin D1, IC₅₀: 100 nM	CDK5/p35, IC₅₀: 13 nM	cdk6/cyclin D3, IC₅₀: 170 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2400 nM		CDK9/Cyclin T, IC₅₀: 10 nM				Pan Inhibitor	99.99%
Riviciclib hydrochloride	CDK1-Cyclin B, IC₅₀: 0.079 μM	cdk2-cyclin A, IC₅₀: 0.224 μM cdk2-cyclin E, IC₅₀: 2.500 μM		cdk4-cyclin D1, IC₅₀: 0.063 μM		cdk6-cyclin D3, IC₅₀: 0.396 μM			CDK9- Cyclin T1, IC₅₀: 0.020 μM CDK9-cyclin H, IC₅₀: 2.900 μM				Pan	98.33%
Purvalanol B	cdc2/cyclin B, IC₅₀: 6 nM cyclin dependent kinase 1-cyclinB, IC₅₀: 6 nM	cdk2/cyclin A, IC₅₀: 6 nM CDK2/cyclinE, IC₅₀: 9 nM		Cdk4/cyclin D1, IC₅₀: 10000 nM	CDK5/p35, IC₅₀: 6 nM								Pan Inhibitor	>97.0%
MC180295	CDK1-Cyclin B, IC₅₀: 138 nM	cdk2-cyclin A, IC₅₀: 233 nM cdk2-cyclin E, IC₅₀: 367 nM	CDK3-Cyclin E, IC₅₀: 399 nM	CDK4-Cyclin D, IC₅₀: 112 nM	cdk5-p35, IC₅₀: 159 nM cdk5-p25, IC₅₀: 186 nM	cdk6-cyclin D3, IC₅₀: 712 nM	CDK7-CycH/MAT1, IC₅₀: 555 nM		CDK9- Cyclin T1, IC₅₀: 5 nM				Pan Inhibitor	98.47%
AMG 925	CDK1, IC₅₀: 1.9 μM	CDK2, IC₅₀: 375 nM		CDK4, IC₅₀: 3 nM		CDK6, IC₅₀: 8 nM							Pan Inhibitor	99.33%
BS-181 hydrochloride	CDK1/cycB, IC₅₀: 8.1 μM	CDK2/Cyc E, IC₅₀: 0.88 μM		CDK4/Cyc D1, IC₅₀: 33 μM	CDK5/p35NCK, IC₅₀: 3 μM	CDK6/cycD1, IC₅₀: 47 μM	CDK7/CycH/MAT1, IC₅₀: 0.021 μM		CDK9/cycT, IC₅₀: 4.2 μM				Pan Inhibitor	>99.0%
Voruciclib hydrochloride	CDK1/cycB, Ki: 5.4 nM CDK1/cyc A, Ki: 9.1 nM			CDK4/Cyc D1, Ki: 3.96 nM		CDK6/cycD1, Ki: 2.92 nM			CDK9/CycT1, Ki: 1.68 nM CDK9/cyc T2, Ki: 0.626 nM				Pan Inhibitor	98.20%
(R)-CR8	Cdk1/cyclin B, IC₅₀: 0.09 μM	cdk2/cyclin A, IC₅₀: 0.072 μM CDK2/cyclinE, IC₅₀: 0.041 μM			Cdk5/p25, IC₅₀: 0.11 μM		CDK7/cyclin H, IC₅₀: 1.1 μM		CDK9/Cyclin T, IC₅₀: 0.18 μM				Pan Inhibitor	>98.0%
K00546	Cdk1/cyclin B, IC₅₀: 0.6 nM	cdk2/cyclin A, IC₅₀: 0.5 nM										CLK1, IC₅₀: 8.9 nM CLK3, IC₅₀: 29.2 nM	Pan Inhibitor	98.78%
JSH-150	Cdk1/cyclin B, IC₅₀: 1.34 μM	cdk2/cyclin A, IC₅₀: 2.86 μM			Cdk5/p25, IC₅₀: 4.64 μM		CDK7/Cyclin H/MNAT1, IC₅₀: 1.72 μM		CDK9/cyclinT1, IC₅₀: 1 nM	CDK14/Cyclin Y, IC₅₀: 1.68 μM	CDK16/Cyclin Y, IC₅₀: 292 nM		Pan Inhibitor	98.36%
NU2058	CDK1, IC₅₀: 26 μM	CDK2, IC₅₀: 17 μM CDK2, Ki: 12 μM											Pan Inhibitor	99.01%
Voruciclib	CDK1/cycB, Ki: 5.4 nM CDK1/cyc A, Ki: 9.1 nM			CDK4/Cyc D1, Ki: 3.96 nM		CDK6/cycD1, Ki: 2.92 nM			CDK9/cyc T2, Ki: 0.626 nM CDK9/CycT1, Ki: 1.68 nM				Pan Inhibitor	99.52%
Alsterpaullone	Cdk1/cyclin B, IC₅₀: 35 nM	cdk2/cyclin A, IC₅₀: 15 nM CDK2/Cyc E, IC₅₀: 200 nM			CDK5/p35, IC₅₀: 40 nM								Pan Inhibitor	>98.0%
NVP-LCQ195	Cdk1/cyclin B, IC₅₀: 2 nM	cdk2/cyclin A, IC₅₀: 2 nM CDK2/cyclinE, IC₅₀: 5 nM	CDK3/Cyclin E, IC₅₀: 42 nM		Cdk5/p25, IC₅₀: 1 nM CDK5/p35, IC₅₀: 1 nM	cdk6/cyclin D3, IC₅₀: 187 nM	CDK7/Cyclin H/MAT1, IC₅₀: 3564 nM		CDK9/cyclinT1, IC₅₀: 15 nM				Pan Inhibitor	99.80%
CAN508	Cdk1/cyclin B, IC₅₀: 44 μM	CDK2/cyclinE, IC₅₀: 20 μM cdk2/cyclin A, IC₅₀: 69 μM		Cdk4/cyclin D1, IC₅₀: 13.5 μM			CDK7/cyclin H, IC₅₀: 26 μM		CDK9/cyclinT1, IC₅₀: 0.35 μM				Pan Inhibitor
NU6140	CDK1-Cyclin B, IC₅₀: 6.6 μM	cdk2-cyclin A, IC₅₀: 0.41 μM		CDK4-Cyclin D, IC₅₀: 5.5 μM	cdk5-p25, IC₅₀: 15 μM		cdk7-cyclin H, IC₅₀: 3.9 μM						Pan Inhibitor	>99.0%
AMG 925 HCl	CDK1, IC₅₀: 1.9 μM	CDK2, IC₅₀: 375 nM		CDK4, IC₅₀: 3 nM		CDK6, IC₅₀: 8 nM							Pan Inhibitor	98.01%
5-Iodo-indirubin-3'-monoxime	Cdk1/cyclin B, IC₅₀: 25 nM				Cdk5/p25, IC₅₀: 20 nM								Pan Inhibitor	99.50%
AT7519 trifluoroacetate	Cdk1/cyclin B, IC₅₀: 210 nM	cdk2/cyclin A, IC₅₀: 47 nM		Cdk4/cyclin D1, IC₅₀: 100 nM	CDK5/p35, IC₅₀: 13 nM	cdk6/cyclin D3, IC₅₀: 170 nM	CDK7/Cyclin H/MAT1, IC₅₀: 2400 nM		CDK9/Cyclin T, IC₅₀: 10 nM				Pan Inhibitor	98.16%
NU6102	Cdk1/cyclin B, IC₅₀: 9.5 nM	CDK2/cyclin A3, IC₅₀: 5.4 nM		CDK4, IC₅₀: 1.6 μM									Pan Inhibitor	>95.0%
NU6027	CDK1, Ki: 2.5 μM	CDK2, Ki: 1.3 μM											Pan Inhibitor
Indirubin-3'-monoxime-5-sulphonic acid	CDK1, IC₅₀: 5 nM				CDK5, IC₅₀: 7 nM								Pan Inhibitor
Indirubin-5-sulfonate	Cdk1/cyclin B, IC₅₀: 55 nM	cdk2/cyclin A, IC₅₀: 35 nM CDK2/cyclinE, IC₅₀: 150 nM		Cdk4/cyclin D1, IC₅₀: 300 nM	CDK5/p35, IC₅₀: 65 nM								Pan Inhibitor
Desmethylglycitein	CDK1	CDK2											Inhibitor	>95.0%

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