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Cat. No.: HY-182906

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XL495

XL495 is an potent, selective and orally active PKMYT1 inhibitor. XL495 inhibits CDK1 Thr14 phosphorylation and induces KAP1 Ser824 phosphorylation in xenograft tumors. XL495 reduces tumor growth in colorectal and breast cancer xenograft models, and achieves tumor regression with DNA-damaging agents in colorectal cancer xenograft models. XL495 can be used for the research of cancer, such as breast cancer and colorectal cancer.

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CAS No.: 3040320-93-9
화학식: C₁₇H₁₆N₄O₂
분자량:308.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

XL495 Chemical Structure

CAS No.: 3040320-93-9

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PKMYT1

CDK1

All Wee1 Isoforms :

PKMYT1

All CDK Isoforms :

In Vivo

XL495 (p.o.) shows antitumor activity in a breast cancer cell line-derived xenograft (CDX) model.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 3040320-93-9
분자량 308.33
화학식 C₁₇H₁₆N₄O₂
SMILES

NC(C1=C(N)[C@@]([C@@]2=C(C)C=CC(O)=C2C)=C3N=CC=NC3=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhu J, et al. Enantioselective Suzuki-Miyaura Chemistry: Route Evolution for the Synthesis of PKMYT1 Inhibitor XL495. J Org Chem. 2026 Apr 17;91(15):5379-5387. [Content Brief]

[2]. Gwinn D, et al. XL495 is a potent, selective, and orally bioavailable inhibitor of PKMYT1[J]. Cancer Research, 2025, 85(8_Supplement_1): 1733-1733.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
순도&문서
References

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XL495

All Wee1 Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

XL495 Related Classifications

HY-182906 Related Classifications