PKMYT1
PKMYT1, or Myt1, is the membrane-associated member of the Wee1 family of inhibitory kinases. Whereas Wee1 acts in the nucleus, Myt1 is anchored to Golgi and endoplasmic-reticulum membranes and phosphorylates cyclin B-CDK1 on Thr14 as well as Tyr15, keeping the complex inactive in the cytoplasm throughout interphase. At the G2/M transition, Myt1 is itself inactivated by phosphorylation, releasing active CDK1 into mitosis. PKMYT1 also restrains CDK2 and helps protect against premature mitotic entry after DNA damage. Because many cancers depend on PKMYT1 to buffer CDK1 activity, the kinase is an emerging combination-therapy target. Recombinant PKMYT1 enables cell-cycle inhibitor research.
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PKMYT1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
