1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK2 Inhibitors

CDK2 Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

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Sorry. There is currently no product that acts on isoform CDK2 together.

Please try each isoform separately.

CDK2 Specific Inhibitors & Antagonists
Product Name CDK2 CDK1 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK14 CDK16 CDK2 Selectivity Purity
SB1317
CDK2, IC50: 13 nM
                    Selective Inhibitor 99.96%
AUZ 454
CDK2(C118L/A144C), Kd: 9.7 nM
CDK2(A144C), Kd: 15.4 nM
CDK2(C118L), Kd: 18.6 nM
CDK2(WT), Kd: 50 nM
CDK2(C118L/A144C-Cyclin B), Kd: 134.1 nM
                    Selective Inhibitor 99.99%
NU6300
CDK2, IC50: 0.16 μM
                    Selective Inhibitor 97.03%
CDK2-IN-4
cdk2/cyclin A, IC50: 44 nM
Cdk1/cyclin B, IC50: 86 μM
                  Selective Inhibitor >97.0%
BGG463
CDK2
                    Selective Inhibitor >98.0%
Desmethylglycitein
CDK2
CDK1
                  Selective Inhibitor
Abemaciclib methanesulfonate
CDK2/cyclinE, IC50: 504 nM
CDK1/cyclinB1, IC50: 1627 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
    Pan Inhibitor 99.95%
Dinaciclib
CDK2, IC50: 1 nM
CDK1, IC50: 3 nM
   
CDK5, IC50: 1 nM
     
CDK9, IC50: 4 nM
    Pan Inhibitor 99.73%
Seliciclib
cdk2/cyclin A, IC50: 0.7 μM
Cdk2/cyclin E2, IC50: 0.7 μM
cdc2/cyclin B, IC50: 0.65 μM
   
CDK5/p35, IC50: 0.16 μM
            Pan Inhibitor 99.94%
Ro-3306
CDK2/cyclinE, Ki: 340 nM
CDK1, Ki: 20 nM
CDK1/cyclinB1, Ki: 35 nM
CDK1/cyclin A, Ki: 110 nM
                  Pan Inhibitor 96.77%
Flavopiridol
CDK2/Cyc E, IC50: 170 nM
CDK1/Cyc B1, IC50: 30 nM
 
CDK4/Cyc D1, IC50: 100 nM
              Pan Inhibitor 99.72%
Abemaciclib
CDK2/cyclinE, IC50: 504 nM
CDK1/cyclinB1, IC50: 1627 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
    Pan Inhibitor 99.69%
PF-06873600
CDK2, Ki: 0.09 nM
   
CDK4, Ki: 0.13 nM
 
CDK6, Ki: 0.16 nM
          Pan Inhibitor 99.98%
CYC065
CDK2
             
CDK9
    Pan Inhibitor 99.78%
SNS-032
CDK2, IC50: 38 nM
CDK1, IC50: 480 nM
 
CDK4, IC50: 925 nM
   
CDK7, IC50: 62 nM
 
CDK9, IC50: 4 nM
    Pan Inhibitor 98.50%
AT7519
cdk2/cyclin A, IC50: 47 nM
Cdk1/cyclin B, IC50: 210 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
    Pan Inhibitor 98.15%
AZD-5438
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
cdk1-cyclin B1, IC50: 16 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
cdk7-cyclin H, IC50: 821 nM
 
cdk9-cyclin T, IC50: 20 nM
    Pan Inhibitor 99.37%
CT7001 hydrochloride
CDK2/cycE1, IC50: 578 nM
         
CDK7/CycH/MAT1, IC50: 41 nM
        Pan Inhibitor 99.98%
CVT-313
cdk2/cyclin A, IC50: 0.5 μM
Cdk1/cyclin B, IC50: 4.2 μM
 
Cdk4/cyclin D1, IC50: 215 μM
              Pan Inhibitor 99.76%
JNJ-7706621
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
Cdk1/cyclin B, IC50: 9 nM
CDK3/Cyclin E, IC50: 58 nM
Cdk4/cyclin D1, IC50: 253 nM
 
CDK6/cyclinD1, IC50: 175 nM
          Pan Inhibitor 99.91%
Milciclib
cyclin A/CDK2, IC50: 45 nM
cyclin E/CDK2, IC50: 363 nM
cyclin B/CDK1, IC50: 398 nM
 
cyclin D1/CDK4, IC50: 160 nM
   
cyclin H/CDK7, IC50: 150 nM
        Pan Inhibitor 99.92%
PHA-767491 hydrochloride
CDK2, IC50: 240 nM
CDK1, IC50: 250 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
    Pan Inhibitor 99.91%
GSK 3 Inhibitor IX
cdk2/cyclin A, IC50: 300 nM
Cdk1/cyclin B, IC50: 320 nM
 
Cdk4/cyclin D1, IC50: 10 μM
CDK5/p35, IC50: 80 nM
            Pan Inhibitor 99.66%
THZ2
CDK2, IC50: 222 nM
CDK1, IC50: 96.9 nM
   
CDK5, IC50: 134 nM
 
CDK7, IC50: 13.9 nM
CDK8, IC50: 6830 nM
CDK9, IC50: 194 nM
    Pan Inhibitor 99.03%
Purvalanol A
cdk2-cyclin E, IC50: 35 nM
cdk2-cyclin A, IC50: 70 nM
cdc2-cyclin B, IC50: 4 nM
 
cdk4-cyclin D1, IC50: 850 nM
cdk5-p35, IC50: 75 nM
            Pan Inhibitor 98.66%
LDC000067
cdk2-cyclin A, IC50: 2441 nM
cdk1-cyclin B1, IC50: 5513 nM
 
cdk4-cyclin D1, IC50: 9242 nM
       
CDK9- Cyclin T1, IC50: 44 nM
    Pan Inhibitor 98.14%
BMS-265246
CDK2/Cyc E, IC50: 9 nM
CDK1/cycB, IC50: 6 nM
 
CDK4/cycD, IC50: 230 nM
              Pan Inhibitor 98.64%
Flavopiridol Hydrochloride
CDK2/Cyc E, IC50: 170 nM
CDK1/Cyc B1, IC50: 30 nM
 
CDK4/Cyc D1, IC50: 100 nM
              Pan Inhibitor 99.74%
PHA-793887
cdk2/cyclin A, IC50: 8 nM
CDK2/cyclinE, IC50: 8 nM
Cdk1/cyclin B, IC50: 60 nM
 
Cdk4/cyclin D1, IC50: 62 nM
Cdk5/p25, IC50: 5 nM
 
CDK7/cyclin H, IC50: 10 nM
 
CDK9/cyclinT1, IC50: 138 nM
    Pan Inhibitor 99.95%
CDKI-73
CDK2, IC50: 3.27 nM
CDK1, IC50: 8.17 nM
 
CDK4, IC50: 8.18 nM
 
CDK6, IC50: 37.68 nM
CDK7, IC50: 134.26 nM
 
CDK9, IC50: 5.78 nM
    Pan Inhibitor 99.58%
Atuveciclib
CDK2/CycE(h), IC50: 1000 nM
CDK1/CycB(h), IC50: 1100 nM
CDK3/CycE(h), IC50: 890 nM
 
CDK5/p35(h), IC50: 1600 nM
     
CDK9/CycT1, IC50: 13 nM
CDK9/CycT1(h), IC50: 6 nM
    Pan Inhibitor 99.42%
R547
CDK2/cyclinE, Ki: 3 nM
Cdk1/cyclin B, Ki: 2 nM
 
CDK4/cyclin D, Ki: 1 nM
              Pan Inhibitor 98.42%
SU9516
CDK2, IC50: 22 nM
CDK1, IC50: 40 nM
 
CDK4, IC50: 200 nM
              Pan Inhibitor 99.76%
AT7519 Hydrochloride
cdk2/cyclin A, IC50: 47 nM
Cdk1/cyclin B, IC50: 210 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
    Pan Inhibitor 99.99%
MC180295
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK1-Cyclin B, IC50: 138 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
CDK7-CycH/MAT1, IC50: 555 nM
 
CDK9- Cyclin T1, IC50: 5 nM
    Pan Inhibitor 98.47%
FN-1501
cdk2/cyclin A, IC50: 2.47 nM
   
Cdk4/cyclin D1, IC50: 0.85 nM
 
CDK6/cyclinD1, IC50: 1.96 nM
          Pan Inhibitor 98.41%
Lerociclib dihydrochloride
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
CDK1/cyclinB1, IC50: 2.4 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
    Pan Inhibitor 98.45%
Purvalanol B
cdk2/cyclin A, IC50: 6 nM
CDK2/cyclinE, IC50: 9 nM
cdc2/cyclin B, IC50: 6 nM
cyclin dependent kinase 1-cyclinB, IC50: 6 nM
 
Cdk4/cyclin D1, IC50: 10000 nM
CDK5/p35, IC50: 6 nM
            Pan Inhibitor >97.0%
Roniciclib
CDK2/cyclinE, IC50: 9 nM
Cdk1/cyclin B, IC50: 7 nM
 
CDK4/cyclin D, IC50: 11 nM
   
CDK7/Cyclin H/MAT1, IC50: 25 nM
 
CDK9/cyclinT1, IC50: 5 nM
    Pan Inhibitor 98.89%
JSH-150
cdk2/cyclin A, IC50: 2.86 μM
Cdk1/cyclin B, IC50: 1.34 μM
   
Cdk5/p25, IC50: 4.64 μM
 
CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
 
CDK9/cyclinT1, IC50: 1 nM
CDK14/Cyclin Y, IC50: 1.68 μM
CDK16/Cyclin Y, IC50: 292 nM
Pan Inhibitor 98.36%
AMG 925
CDK2, IC50: 375 nM
CDK1, IC50: 1.9 μM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
          Pan Inhibitor 99.33%
FMF-04-159-2
CDK2, IC50: 256 nM (in NanoBRET assay)
               
CDK14/Cyclin Y, IC50: 39.6 nM (in NanoBRET assay)
  Pan Inhibitor 99.34%
Riviciclib hydrochloride
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
CDK1-Cyclin B, IC50: 0.079 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
    Pan 98.33%
Bisindolylmaleimide X hydrochloride
CDK2, IC50: 200 nM
                    Pan Antagonist 98.53%
(R)​-​CR8
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
Cdk1/cyclin B, IC50: 0.09 μM
   
Cdk5/p25, IC50: 0.11 μM
 
CDK7/cyclin H, IC50: 1.1 μM
 
CDK9/Cyclin T, IC50: 0.18 μM
    Pan Inhibitor
NU6140
cdk2-cyclin A, IC50: 0.41 μM
CDK1-Cyclin B, IC50: 6.6 μM
 
CDK4-Cyclin D, IC50: 5.5 μM
cdk5-p25, IC50: 15 μM
 
cdk7-cyclin H, IC50: 3.9 μM
        Pan Inhibitor >99.0%
Alsterpaullone
cdk2/cyclin A, IC50: 15 nM
CDK2/Cyc E, IC50: 200 nM
Cdk1/cyclin B, IC50: 35 nM
   
CDK5/p35, IC50: 40 nM
            Pan Inhibitor 97.30%
AMG 925 HCl
CDK2, IC50: 375 nM
CDK1, IC50: 1.9 μM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
          Pan Inhibitor 98.01%
NU2058
CDK2, IC50: 17 μM
CDK2, Ki: 12 μM
CDK1, IC50: 26 μM
                  Pan Inhibitor 99.01%
(R)​-​CR8 trihydrochloride
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
CDK1/cyclinB1, IC50: 0.09 μM
   
Cdk5/p25, IC50: 0.11 μM
 
CDK7/cyclin H, IC50: 1.1 μM
 
CDK9/Cyclin T, IC50: 0.18 μM
    Pan Inhibitor
AT7519 trifluoroacetate
cdk2/cyclin A, IC50: 47 nM
Cdk1/cyclin B, IC50: 210 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
    Pan Inhibitor 98.16%
PHA-767491
CDK2, IC50: 240 nM
CDK1, IC50: 250 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
    Pan Inhibitor
BS-181 hydrochloride
CDK2/Cyc E, IC50: 0.88 μM
CDK1/cycB, IC50: 8.1 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
 
CDK9/cycT, IC50: 4.2 μM
    Pan Inhibitor
NVP-LCQ195
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
Cdk1/cyclin B, IC50: 2 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
cdk6/cyclin D3, IC50: 187 nM
CDK7/Cyclin H/MAT1, IC50: 3564 nM
 
CDK9/cyclinT1, IC50: 15 nM
    Pan Inhibitor 98.99%
IIIM-290
CDK2/A, IC50: 90 nM
             
CDK9/T1, IC50: 94 nM
    Pan Inhibitor
Riviciclib
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.540 μM
CDK1-Cyclin B, IC50: 0.079 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
    Pan Inhibitor
PROTAC CDK2/9 Degrader-1
CDK2, DC50: 62 nM
             
CDK9, DC50: 33 nM
    Pan Inhibitor
Lerociclib
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
CDK1/cyclinB1, IC50: 2.4 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
    Pan Inhibitor
Indirubin-5-sulfonate
cdk2/cyclin A, IC50: 35 nM
CDK2/cyclinE, IC50: 150 nM
Cdk1/cyclin B, IC50: 55 nM
 
Cdk4/cyclin D1, IC50: 300 nM
CDK5/p35, IC50: 65 nM
            Pan Inhibitor