142273-20-9
Chemical Structure
Kenpaullone
Synonym(s): 9-Bromopaullone; NSC-664704
- CAS No.: 142273-20-9
- Formula:C16H11BrN2O
- Molecular Weight:327.18
IUPAC Name: 9-bromo-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one
InChIKey: QQUXFYAWXPMDOE-UHFFFAOYSA-N
SMILES: O=C1NC2=CC=CC=C2C(NC3=C4C=C(Br)C=C3)=C4C1
Biological Activity: Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kenpaullone | 98.20% | Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro. | ||||||||||||||||||||
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Keywords
