1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. WD2000-012547

WD2000-012547 

Cat. No.: HY-U00223
Handling Instructions

WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.

For research use only. We do not sell to patients.

WD2000-012547 Chemical Structure

WD2000-012547 Chemical Structure

CAS No. : 283172-68-9

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Description

WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.

IC50 & Target[1]

PARP-1

8.221 (pKi)

In Vitro

Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pKi of 8.221[1].

Molecular Weight

262.31

Formula

C₁₇H₁₄N₂O

CAS No.

283172-68-9

SMILES

O=C(NCC1)C2=CC=CC3=C2C1=C(C4=CC=CC=C4)N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

WD2000-012547PARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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