PARP

PARP Related Products (66):

By Type:	Pan (12) Selective (1)
By Effects:	Inhibitors (52) Agonist (1) Activators (4) Inducers (4)

Cat. No.	Product Name	Effect	Purity

HY-13688A

PJ34	Inhibitor	98.01%
PJ34 is a potent specific inhibitor of PARPl/2 with IC₅₀ of 110 nM and 86 nM, respectively.

HY-104044

Pamiparib	Inhibitor	99.97%
Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor, with IC₅₀ values of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively.

HY-N0674

Dehydrocorydaline	Inhibitor	99.77%
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP.

HY-13688

PJ34 hydrochloride	Inhibitor	99.10%
PJ34 hydrochloride is an inhibitor of PARP1/2 with IC₅₀ of 110 nM and 86 nM, respectively.

HY-145471

KSQ-4279	Inhibitor	99.94%
KSQ-4279 (USP1-IN-1, Formula I) is a USP1 and PARP inhibitor (extracted from patent WO2021163530).

HY-12022

3-Aminobenzamide	Inhibitor	99.92%
3-Aminobenzamide (PARP-IN-1) is a potent inhibitor of PARP with IC₅₀ of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

HY-108413

Talazoparib tosylate	Inhibitor	99.72%
Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC₅₀ of 0.57 nM for PARP1.

HY-108631

EB-47 dihydrochloride	Inhibitor	99.72%
EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC₅₀ value of 45 nM, shows modest potency against ARTD5 with an IC₅₀ value of 410 nM.

HY-13968

JW 55	Inhibitor	99.94%
JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).

HY-12975

AZ6102	Inhibitor	99.65%
AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC₅₀s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC₅₀s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively.

HY-137450

Senaparib	Inhibitor	99.44%
Senaparib (IMP4297) is a highly potent, selective and orally active PARP1/2 inhibitor.

HY-130644

iRucaparib-AP6	Inhibitor	99.82%
iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.

HY-100828

BGP-15	Inhibitor	≥98.0%
BGP-15 is a PARP inhibitor, with an IC₅₀ and a K_i of 120 and 57 μM, respectively.

HY-119653

AZ9482	Inhibitor	98.17%
AZ9482 is a triple PARP1/2/6 inhibitor, with IC₅₀ values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively.

HY-15045

INO-1001	Inhibitor	98.19%
INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor.

HY-W016412

Coenzyme Q0	Inhibitor	≥99.0%
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea.

HY-100862

BRCA1-IN-2	Inhibitor	98.39%
BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC₅₀ of 0.31 μM and a K_d of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)₂/protein interactions.

HY-114869

DPQ	Inhibitor	≥99.0%
DPQ is a potent PARP-1 inhibitor.

HY-N6818

5,7,4'-Trimethoxyflavone	Activator	99.78%
5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand.

HY-15044

NU1025	Inhibitor	≥98.0%
NU1025 is a potent PARP inhibitor with an IC₅₀ of 400 nM and a K_i of 48 nM.

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