Oxychlororaphine

Name: Oxychlororaphine
Brand: MedChemExpress
SKU: HY-W042191
Rating: 4.5 (1 reviews)

Cat. No.: HY-W042191 Purity: 98.90%: FAQs
Data Sheet SDS COA Handling Instructions

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Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer.

For research use only. We do not sell to patients.

Oxychlororaphine Chemical Structure

CAS No. : 550-89-0

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 116	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 243	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 1600	In-stock	Estimated Time of Arrival: December 31
1 g	USD 2560	In-stock	Estimated Time of Arrival: December 31
5 g	USD 4864	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC₅₀ values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM^[2].
Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein^[2].
Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase^[2].
Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	A549, HeLa, and SW480 cancer cell lines
Concentration:	1, 2, 4, 8, 16, 32, 64, 128, and 256 μM
Incubation Time:	24 hours
Result:	Inhibited cell proliferative in a dose-dependent manner.

Molecular Weight

223.23

Formula

C₁₃H₉N₃O

CAS No.

550-89-0

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C1=CC=CC2=NC3=CC=CC=C3N=C21)N

Structure Classification

Others

Initial Source

Microorganisms

Phytopathogenic bacteria

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4797 mL	22.3984 mL	44.7968 mL
5 mM	0.8959 mL	4.4797 mL	8.9594 mL
10 mM	0.4480 mL	2.2398 mL	4.4797 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.90%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (251 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Li S, et, al. Comparative metabolomics and transcriptomics analyses provide insights into the high-yield mechanism of phenazines biosynthesis in Pseudomonas chlororaphis GP72. J Appl Microbiol. 2022 Nov;133(5):2790-2801. [Content Brief]

[2]. Ali HM, et, al. Isolation of Bioactive Phenazine-1-Carboxamide from the Soil Bacterium Pantoea agglomerans and Study of Its Anticancer Potency on Different Cancer Cell Lines. J AOAC Int. 2016 Sep;99(5):1233-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4797 mL	22.3984 mL	44.7968 mL	111.9921 mL
	5 mM	0.8959 mL	4.4797 mL	8.9594 mL	22.3984 mL
	10 mM	0.4480 mL	2.2398 mL	4.4797 mL	11.1992 mL
	15 mM	0.2986 mL	1.4932 mL	2.9865 mL	7.4661 mL
	20 mM	0.2240 mL	1.1199 mL	2.2398 mL	5.5996 mL
	25 mM	0.1792 mL	0.8959 mL	1.7919 mL	4.4797 mL
	30 mM	0.1493 mL	0.7466 mL	1.4932 mL	3.7331 mL
	40 mM	0.1120 mL	0.5600 mL	1.1199 mL	2.7998 mL