Cat. No.: HY-W042191

Oxychlororaphine

Customer Review

Based on 1 Customer Validation

Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer.

For research use only. We do not sell to patients.

Purity: 98.63%
CAS No.: 550-89-0
Formula: C₁₃H₉N₃O
Molecular Weight:223.23

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Oxychlororaphine Chemical Structure

CAS No.: 550-89-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Caspase Isoforms :

All Bcl-2 Family Isoforms :

All PARP Isoforms :

In Vitro

Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC₅₀ values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM^[2].
Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein^[2].
Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase^[2].
Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

A549, HeLa, and SW480 cancer cell lines
Concentration:

1, 2, 4, 8, 16, 32, 64, 128, and 256 μM
Incubation Time:

24 hours
Result:

Inhibited cell proliferative in a dose-dependent manner.

Chemical Information

CAS No. 550-89-0
Appearance Solid
Molecular Weight 223.23
Formula C₁₃H₉N₃O
Color Light yellow to brown
SMILES

O=C(C1=CC=CC2=NC3=CC=CC=C3N=C21)N
Structure Classification
- Others
Initial Source
- Microorganisms
Phytopathogenic bacteria
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4797 mL

22.3984 mL

44.7968 mL

5 mM

0.8959 mL

4.4797 mL

8.9594 mL

10 mM

0.4480 mL

2.2398 mL

4.4797 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li S, et, al. Comparative metabolomics and transcriptomics analyses provide insights into the high-yield mechanism of phenazines biosynthesis in Pseudomonas chlororaphis GP72. J Appl Microbiol. 2022 Nov;133(5):2790-2801. [Content Brief]

[2]. Ali HM, et, al. Isolation of Bioactive Phenazine-1-Carboxamide from the Soil Bacterium Pantoea agglomerans and Study of Its Anticancer Potency on Different Cancer Cell Lines. J AOAC Int. 2016 Sep;99(5):1233-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4797 mL	22.3984 mL	44.7968 mL	111.9921 mL
	5 mM	0.8959 mL	4.4797 mL	8.9594 mL	22.3984 mL
	10 mM	0.4480 mL	2.2398 mL	4.4797 mL	11.1992 mL
	15 mM	0.2986 mL	1.4932 mL	2.9865 mL	7.4661 mL
	20 mM	0.2240 mL	1.1199 mL	2.2398 mL	5.5996 mL
	25 mM	0.1792 mL	0.8959 mL	1.7919 mL	4.4797 mL
	30 mM	0.1493 mL	0.7466 mL	1.4932 mL	3.7331 mL
	40 mM	0.1120 mL	0.5600 mL	1.1199 mL	2.7998 mL

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Oxychlororaphine

MCE Kinase Hinge Binder Fragment Library

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Natural Product Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antifungal Compound Library

Ferroptosis Compound Library

Pyroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Microbial Metabolite Library

Mitochondria-Targeted Compound Library

Transcription Factor-Targeted Library

Anti-Cancer Natural Product Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Bacteria-Sourced Compound Library

Mass Spectrometry Natural Product Library

All Caspase Isoforms

All Bcl-2 Family Isoforms

All PARP Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Oxychlororaphine Related Classifications

HY-W042191 Related Classifications