2. Signaling Pathways
  3. Apoptosis
  4. Caspase
  5. Caspase 5 Isoform

Caspase 5

Caspase-5 is a human inflammatory caspase and a component of the non-canonical inflammasome that senses intracellular lipopolysaccharide from Gram-negative bacteria[1]. Mechanistically, intracellular LPS promotes rapid oligomerization of caspase-11/4/5, leading to pyroptosis and secretion of IL-1β and IL-18[1]. In human monocytes, Pseudomonas aeruginosa outer membrane vesicles activate the noncanonical inflammasome through caspase-5, supporting its use in Gram-negative infection and OMV vaccine models[2]. Compared with related isoforms, caspase-5, but not caspase-4, is required for inflammasome activation by P. aeruginosa OMVs, whereas transfected free LPS induces inflammasome responses through caspase-4[2]. Therefore, caspase-4 and caspase-5 differentially recognize LPS depending on physical form or route of delivery into the cell[2]. Current retrieved evidence supports caspase-5 pathway studies using OMVs, CRISPR/Cas9 knockout THP-1 cells, IL-1β release, caspase-1 cleavage, and pyroptosis readouts, but does not establish a selective caspase-5 agonist or inhibitor[2].

Caspase 5 Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-P1001
    Ac-DEVD-CHO
    		Inhibitor 99.76%
    Ac-DEVD-CHO is a Caspase-3 inhibitor with a Ki value of 230 pM.
  • HY-111675
    Ac-FLTD-CMK
    		Inhibitor 99.18%
    Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3.
  • HY-B1138
    Fenbufen
    		Inhibitor 98.50%
    Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor.
  • HY-12412
    ML132
    		Inhibitor 98.75%
    ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 value of 0.023 nM. ML132 has good stability and can be used as a caspase 1 molecular probe. ML132 is applicable to research in the fields of anticancer and anti-inflammatory studies.
  • HY-N8508
    Myrothecine A
    		Activator
    Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively.