1. Apoptosis
  2. Caspase
  3. ML132

ML132 (Synonyms: NCGC 00185682)

Cat. No.: HY-12412 Purity: 98.75%
Handling Instructions

ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM.

For research use only. We do not sell to patients.

ML132 Chemical Structure

ML132 Chemical Structure

CAS No. : 1230628-71-3

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM.

IC50 & Target[1]

Caspase-1

0.316 nM (IC50)

Molecular Weight

477.94

Formula

C₂₂H₂₈ClN₅O₅

CAS No.

1230628-71-3

SMILES

ClC1=CC(C(N[[email protected]@H](C(C)(C)C)C(N2CCC[[email protected]]2C(N[[email protected]@H](CC(O)=O)C#N)=O)=O)=O)=CC=C1N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (418.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0923 mL 10.4616 mL 20.9231 mL
5 mM 0.4185 mL 2.0923 mL 4.1846 mL
10 mM 0.2092 mL 1.0462 mL 2.0923 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.35 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ML132NCGC 00185682ML 132ML-132NCGC00185682NCGC-00185682CaspaseInhibitorinhibitorinhibit

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ML132
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HY-12412
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