2. Signaling Pathways
  3. Apoptosis
  4. Caspase
  5. Caspase 10 Isoform

Caspase 10

Caspase-10 (CASP10) functions as an initiator caspase in death receptor signaling and can initiate Fas- and TRAIL-receptor-mediated apoptosis independently of caspase-8[1]. Mechanistically, caspase-10 is recruited to native TRAIL and CD95/Fas death-inducing signaling complexes (DISC) in a FADD-dependent manner, but it cannot functionally substitute caspase-8 in caspase-8-deficient cells[2]. Compared with caspase-8, caspase-10 acts as a regulatory isoform that reduces caspase-8 DISC association and activation, thereby switching CD95L signaling toward NF-κB activation and cell survival[3]. Caspase-8 and caspase-10 also activate NF-κB through RIP, NIK, and IKKα kinases, linking apoptotic machinery to inflammatory gene regulation[4]. In primary biliary cholangitis models, caspase-10 knockout macrophages showed stronger regulation of inflammatory cell death than caspase-8 knockout macrophages, including necroptosis and pyroptosis[5]. CASP10 mutations were reported in autoimmune lymphoproliferative syndrome type II with defective lymphocyte and dendritic cell apoptosis, but later human variant analyses found CASP10 dispensable for Fas-mediated apoptosis and unlikely to drive ALPS pathogenesis[6][7]. Substrate studies show overlapping caspase-8/caspase-10 cleavage preferences for RIP and PAK2, but distinct Bid cleavage patterns[8]. For experimental applications, the caspase-10 inhibitor z-AEVD-Fmk reduced terminal erythroid differentiation in CD36+ cultures, supporting pathway-specific functional testing[9].

References:

Cat. No. Product Name Effect Purity
  • HY-12305
    Q-VD-OPh
    		Inhibitor 99.92%
    Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.
  • HY-P1001
    Ac-DEVD-CHO
    		Inhibitor 99.76%
    Ac-DEVD-CHO is a Caspase-3 inhibitor with a Ki value of 230 pM.
  • HY-103667
    2-HBA
    		Activator 99.46%
    2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
  • HY-125305
    Z-AEVD-FMK
    		Inhibitor
    Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells.
  • HY-181955
    MS1129
    		Activator
    MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins. MS1129 upregulates TRAIL, DR4 and DR5 proteins, downregulates the decoy receptor DcR2, and activates TRAIL-dependent apoptosis via the HIF-1/2 and Caspase-10 pathways. MS1129 is applicable to the research of VHL-deficient clear cell renal cell carcinoma.
  • HY-180948
    PZ-11
    PZ-11 is a derivative of thiazolidinedione with anti-tumor activity. PZ-11 can induce cancer cells apoptosis by downregulating anti-apoptotic gene AIFM1, BAG3 and BIRC3 and regulating pro-apoptotic gene BAD, HRK, CASP10 and CASP10. PZ-11 can be used for research of breast cancer.
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity